Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women
OBJECTIVE: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone-IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH-IGF-I axis is alter...
Published in: | European Journal of Endocrinology |
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crbioscientif:10.1530/eje.0.1440283 2023-05-15T17:45:08+02:00 Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women Soderberg, S Ahren, B Eliasson, M Dinesen, B Brismar, K Olsson, T 2001 http://dx.doi.org/10.1530/eje.0.1440283 https://eje.bioscientifica.com/view/journals/eje/144/3/283.xml unknown Bioscientifica European Journal of Endocrinology page 283-290 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2001 crbioscientif https://doi.org/10.1530/eje.0.1440283 2022-09-04T14:47:03Z OBJECTIVE: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone-IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH-IGF-I axis is altered with increasing obesity is not known. We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study. DESIGN AND SUBJECTS: Healthy subjects (n=158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) population were studied with a cross-sectional design. METHODS: Anthropometric measurements (body mass index (BMI) and waist circumference) and oral glucose tolerance tests were performed. Radioimmunoassays were used for the analyses of leptin, IGF-I and IGFBP-1, and ELISAs for specific insulin and proinsulin. RESULTS: Leptin inversely correlated to IGFBP-1 in non-obese men (P<0.05) and obese postmenopausal women (P<0.05). In contrast, leptin did not correlate to IGF-I. IGFBP-1 was also significantly associated with proinsulin in non-obese men (P<0.01) and non-obese premenopausal women (P<0.05). The association between leptin and IGFBP-1 was lost after adjustment for insulin. In multivariate analyses taking measures of adiposity into account, low proinsulin, and IGF-I in combination with old age, but not leptin, predicted high IGFBP-1 levels. CONCLUSIONS: Leptin was inversely associated with IGFBP-1 in non-obese men and obese postmenopausal women, and proinsulin was inversely associated with IGFBP-1 in non-obese men and premenopausal women. However, these associations were lost with increasing central obesity in men and premenopausal women and after control for insulin. Therefore, this study suggests (i) that leptin is of minor importance for regulation of IGFBP-1 levels and (ii) that the insulin resistance ... Article in Journal/Newspaper Northern Sweden Bioscientifica (via Crossref) European Journal of Endocrinology 283 290 |
institution |
Open Polar |
collection |
Bioscientifica (via Crossref) |
op_collection_id |
crbioscientif |
language |
unknown |
topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Soderberg, S Ahren, B Eliasson, M Dinesen, B Brismar, K Olsson, T Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
OBJECTIVE: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone-IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH-IGF-I axis is altered with increasing obesity is not known. We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study. DESIGN AND SUBJECTS: Healthy subjects (n=158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) population were studied with a cross-sectional design. METHODS: Anthropometric measurements (body mass index (BMI) and waist circumference) and oral glucose tolerance tests were performed. Radioimmunoassays were used for the analyses of leptin, IGF-I and IGFBP-1, and ELISAs for specific insulin and proinsulin. RESULTS: Leptin inversely correlated to IGFBP-1 in non-obese men (P<0.05) and obese postmenopausal women (P<0.05). In contrast, leptin did not correlate to IGF-I. IGFBP-1 was also significantly associated with proinsulin in non-obese men (P<0.01) and non-obese premenopausal women (P<0.05). The association between leptin and IGFBP-1 was lost after adjustment for insulin. In multivariate analyses taking measures of adiposity into account, low proinsulin, and IGF-I in combination with old age, but not leptin, predicted high IGFBP-1 levels. CONCLUSIONS: Leptin was inversely associated with IGFBP-1 in non-obese men and obese postmenopausal women, and proinsulin was inversely associated with IGFBP-1 in non-obese men and premenopausal women. However, these associations were lost with increasing central obesity in men and premenopausal women and after control for insulin. Therefore, this study suggests (i) that leptin is of minor importance for regulation of IGFBP-1 levels and (ii) that the insulin resistance ... |
format |
Article in Journal/Newspaper |
author |
Soderberg, S Ahren, B Eliasson, M Dinesen, B Brismar, K Olsson, T |
author_facet |
Soderberg, S Ahren, B Eliasson, M Dinesen, B Brismar, K Olsson, T |
author_sort |
Soderberg, S |
title |
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_short |
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_full |
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_fullStr |
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_full_unstemmed |
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_sort |
circulating igf binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
publisher |
Bioscientifica |
publishDate |
2001 |
url |
http://dx.doi.org/10.1530/eje.0.1440283 https://eje.bioscientifica.com/view/journals/eje/144/3/283.xml |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
European Journal of Endocrinology page 283-290 ISSN 0804-4643 1479-683X |
op_doi |
https://doi.org/10.1530/eje.0.1440283 |
container_title |
European Journal of Endocrinology |
container_start_page |
283 |
op_container_end_page |
290 |
_version_ |
1766147913061236736 |