Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
Objective Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among us...
Published in: | European Journal of Endocrinology |
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Bioscientifica
2021
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Online Access: | http://dx.doi.org/10.1530/eje-20-0877 https://eje.bioscientifica.com/view/journals/eje/184/2/EJE-20-0877.xml https://eje.bioscientifica.com/downloadpdf/journals/eje/184/2/EJE-20-0877.xml |
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crbioscientif:10.1530/eje-20-0877 2023-05-15T18:34:51+02:00 Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population Stensen, Dina B Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U E Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie 2021 http://dx.doi.org/10.1530/eje-20-0877 https://eje.bioscientifica.com/view/journals/eje/184/2/EJE-20-0877.xml https://eje.bioscientifica.com/downloadpdf/journals/eje/184/2/EJE-20-0877.xml unknown Bioscientifica http://creativecommons.org/licenses/by/4.0/ CC-BY European Journal of Endocrinology volume 184, issue 2, page 333-342 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2021 crbioscientif https://doi.org/10.1530/eje-20-0877 2022-11-04T15:03:52Z Objective Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among users of progestin-only contraceptives. The aim of this study was to investigate the possible associations between circulating sex-steroid hormones and nasal carriage of Staphylococcus aureus in a general population. Methods In the population-based sixth Tromsø study (2007–2008) nurses collected nasal swab samples from 724 women aged 30–87 not using any exogenous hormones, and 700 of the women had a repeated nasal swab taken (median interval 28 days). We analysed a panel of serum sex-steroids by liquid chromatography tandem mass spectrometry, and collected information about lifestyle, health and anthropometric measures. Multivariable logistic regression was used to study the association between circulating sex-steroids and Staphylococcus aureus carriage (one swab) and persistent carriage (two swabs), while adjusting for potential confounding factors. Women in luteal phase were excluded in the analysis of androgens. Results Staphylococcus aureus persistent nasal carriage prevalence was 22%. One standard deviation increase in testosterone and bioavailable testosterone was associated with lower odds of persistent nasal carriage, (OR = 0.57; 95% CI = 0.35–0.92 and OR = 0.52, 95% CI = 0.30–0.92) respectively. Analysis stratified by menopause gave similar findings. Persistent carriers had lower average levels of androstenedione and DHEA, however, not statistically significant. Conclusion This large population-based study supports that women with lower levels of circulating testosterone may have increased probability of Staphylococcus aureus persistent carriage. Article in Journal/Newspaper Tromsø Bioscientifica (via Crossref) Tromsø European Journal of Endocrinology 184 2 337 346 |
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Open Polar |
collection |
Bioscientifica (via Crossref) |
op_collection_id |
crbioscientif |
language |
unknown |
topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Stensen, Dina B Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U E Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
Objective Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among users of progestin-only contraceptives. The aim of this study was to investigate the possible associations between circulating sex-steroid hormones and nasal carriage of Staphylococcus aureus in a general population. Methods In the population-based sixth Tromsø study (2007–2008) nurses collected nasal swab samples from 724 women aged 30–87 not using any exogenous hormones, and 700 of the women had a repeated nasal swab taken (median interval 28 days). We analysed a panel of serum sex-steroids by liquid chromatography tandem mass spectrometry, and collected information about lifestyle, health and anthropometric measures. Multivariable logistic regression was used to study the association between circulating sex-steroids and Staphylococcus aureus carriage (one swab) and persistent carriage (two swabs), while adjusting for potential confounding factors. Women in luteal phase were excluded in the analysis of androgens. Results Staphylococcus aureus persistent nasal carriage prevalence was 22%. One standard deviation increase in testosterone and bioavailable testosterone was associated with lower odds of persistent nasal carriage, (OR = 0.57; 95% CI = 0.35–0.92 and OR = 0.52, 95% CI = 0.30–0.92) respectively. Analysis stratified by menopause gave similar findings. Persistent carriers had lower average levels of androstenedione and DHEA, however, not statistically significant. Conclusion This large population-based study supports that women with lower levels of circulating testosterone may have increased probability of Staphylococcus aureus persistent carriage. |
format |
Article in Journal/Newspaper |
author |
Stensen, Dina B Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U E Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie |
author_facet |
Stensen, Dina B Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U E Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie |
author_sort |
Stensen, Dina B |
title |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_short |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_full |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_fullStr |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_full_unstemmed |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_sort |
circulating sex-steroids and staphylococcus aureus nasal carriage in a general female population |
publisher |
Bioscientifica |
publishDate |
2021 |
url |
http://dx.doi.org/10.1530/eje-20-0877 https://eje.bioscientifica.com/view/journals/eje/184/2/EJE-20-0877.xml https://eje.bioscientifica.com/downloadpdf/journals/eje/184/2/EJE-20-0877.xml |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Endocrinology volume 184, issue 2, page 333-342 ISSN 0804-4643 1479-683X |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1530/eje-20-0877 |
container_title |
European Journal of Endocrinology |
container_volume |
184 |
container_issue |
2 |
container_start_page |
337 |
op_container_end_page |
346 |
_version_ |
1766219812145463296 |