Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study
Objective The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult popu...
Published in: | European Journal of Endocrinology |
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Online Access: | http://dx.doi.org/10.1530/eje-16-1037 https://eje.bioscientifica.com/view/journals/eje/176/5/625.xml https://syndication.highwire.org/content/doi/10.1530/EJE-16-1037 |
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crbioscientif:10.1530/eje-16-1037 2023-05-15T18:34:21+02:00 Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study Lerstad, Gunhild Brodin, Ellen E Svartberg, Johan Jorde, Rolf Brox, Jan Brækkan, Sigrid K Hansen, John-Bjarne 2017 http://dx.doi.org/10.1530/eje-16-1037 https://eje.bioscientifica.com/view/journals/eje/176/5/625.xml https://syndication.highwire.org/content/doi/10.1530/EJE-16-1037 unknown Bioscientifica European Journal of Endocrinology volume 176, issue 5, page 625-634 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2017 crbioscientif https://doi.org/10.1530/eje-16-1037 2022-05-11T10:18:38Z Objective The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult population. Design Population-based cohort. Methods A total of 27 712 subjects (25–87 years) who participated in Tromsø 4 (1994–1995) and Tromsø 5 (2001–2002) surveys were included in the study, and total calcium and PTH were measured in 27 685 and 8547 subjects respectively. Incident VTE was recorded through December 31, 2012. Cox-regression models with calcium and PTH as time-varying exposures were used to calculate hazard ratios (HR) of VTE by quartiles of calcium and PTH. Quartiles of calcium and PTH were also combined to assess the effect of discordants of both PTH and calcium (e.g. highest and lowest quartiles of both calcium and PTH) on VTE risk using the middle two quartiles as reference. Results There were 712 VTEs during 15.0 years of median follow-up. Serum levels of calcium and PTH were not associated with risk of VTE. However, subjects with discordant high serum levels of both calcium and PTH (calcium ≥2.45 mmol/L and PTH ≥4.0 pmol/L) had increased risk of VTE compared to those in subjects with normal calcium and PTH (multivariable HR: 1.78, 95% CI: 1.12–2.84). Conclusions Serum levels of calcium and PTH separately were not associated with future risk of VTE, but subjects with high levels of both calcium and PTH had increased risk of VTE compared to those in subjects with normal levels. Article in Journal/Newspaper Tromsø Bioscientifica (via Crossref) Tromsø European Journal of Endocrinology 176 5 625 634 |
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Open Polar |
collection |
Bioscientifica (via Crossref) |
op_collection_id |
crbioscientif |
language |
unknown |
topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Lerstad, Gunhild Brodin, Ellen E Svartberg, Johan Jorde, Rolf Brox, Jan Brækkan, Sigrid K Hansen, John-Bjarne Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
Objective The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult population. Design Population-based cohort. Methods A total of 27 712 subjects (25–87 years) who participated in Tromsø 4 (1994–1995) and Tromsø 5 (2001–2002) surveys were included in the study, and total calcium and PTH were measured in 27 685 and 8547 subjects respectively. Incident VTE was recorded through December 31, 2012. Cox-regression models with calcium and PTH as time-varying exposures were used to calculate hazard ratios (HR) of VTE by quartiles of calcium and PTH. Quartiles of calcium and PTH were also combined to assess the effect of discordants of both PTH and calcium (e.g. highest and lowest quartiles of both calcium and PTH) on VTE risk using the middle two quartiles as reference. Results There were 712 VTEs during 15.0 years of median follow-up. Serum levels of calcium and PTH were not associated with risk of VTE. However, subjects with discordant high serum levels of both calcium and PTH (calcium ≥2.45 mmol/L and PTH ≥4.0 pmol/L) had increased risk of VTE compared to those in subjects with normal calcium and PTH (multivariable HR: 1.78, 95% CI: 1.12–2.84). Conclusions Serum levels of calcium and PTH separately were not associated with future risk of VTE, but subjects with high levels of both calcium and PTH had increased risk of VTE compared to those in subjects with normal levels. |
format |
Article in Journal/Newspaper |
author |
Lerstad, Gunhild Brodin, Ellen E Svartberg, Johan Jorde, Rolf Brox, Jan Brækkan, Sigrid K Hansen, John-Bjarne |
author_facet |
Lerstad, Gunhild Brodin, Ellen E Svartberg, Johan Jorde, Rolf Brox, Jan Brækkan, Sigrid K Hansen, John-Bjarne |
author_sort |
Lerstad, Gunhild |
title |
Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
title_short |
Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
title_full |
Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
title_fullStr |
Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
title_full_unstemmed |
Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study |
title_sort |
associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the tromsø study |
publisher |
Bioscientifica |
publishDate |
2017 |
url |
http://dx.doi.org/10.1530/eje-16-1037 https://eje.bioscientifica.com/view/journals/eje/176/5/625.xml https://syndication.highwire.org/content/doi/10.1530/EJE-16-1037 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Endocrinology volume 176, issue 5, page 625-634 ISSN 0804-4643 1479-683X |
op_doi |
https://doi.org/10.1530/eje-16-1037 |
container_title |
European Journal of Endocrinology |
container_volume |
176 |
container_issue |
5 |
container_start_page |
625 |
op_container_end_page |
634 |
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1766219057707614208 |