Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study
Background and objective Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obes...
Published in: | European Journal of Endocrinology |
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Online Access: | http://dx.doi.org/10.1530/eje-15-0839 https://eje.bioscientifica.com/view/journals/eje/173/6/863.xml |
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crbioscientif:10.1530/eje-15-0839 2023-05-15T17:42:48+02:00 Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study Vimaleswaran, Karani S Cavadino, Alana Verweij, Niek Nolte, Ilja M Leach, Irene Mateo _, _ Auvinen, Juha Veijola, Juha Elliott, Paul Penninx, Brenda W Snieder, Harold Järvelin, Marjo-Riitta van der Harst, Pim Cohen, Robert D Boucher, Barbara J Hyppönen, Elina 2015 http://dx.doi.org/10.1530/eje-15-0839 https://eje.bioscientifica.com/view/journals/eje/173/6/863.xml unknown Bioscientifica http://creativecommons.org/licenses/by/3.0/deed.en_GB CC-BY European Journal of Endocrinology volume 173, issue 6, page 863-872 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2015 crbioscientif https://doi.org/10.1530/eje-15-0839 2022-09-04T14:47:11Z Background and objective Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obesity and alcohol intake. To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations ( n =20 242). Design and methods The study populations included the Northern Finland Birth Cohort 1966 ( n =4996), Netherlands Study of Depression and Anxiety ( n =1883) and LifeLines Cohort Study ( n =13 363). Interactions between the polymorphisms and obesity and alcohol intake on dichotomised ALT and GGT levels were assessed using logistic regression and the likelihood ratio test. Results In the meta-analysis of the three cohorts, none of the three UCP2 polymorphisms were associated with GGT or ALT levels. There was no evidence for interaction between the polymorphisms and alcohol intake on GGT and ALT levels. In contrast, the association of WC and BMI with GGT levels varied by rs659366 genotype ( P interaction =0.03 and 0.007, respectively; adjusted for age, gender, high alcohol intake, diabetes, hypertension and serum lipid concentrations). Conclusion In conclusion, our findings in 20 242 individuals suggest that UCP2 gene polymorphisms may cause liver dysfunction through the interaction with body fat rather than alcohol intake. Article in Journal/Newspaper Northern Finland Bioscientifica (via Crossref) European Journal of Endocrinology 173 6 863 872 |
institution |
Open Polar |
collection |
Bioscientifica (via Crossref) |
op_collection_id |
crbioscientif |
language |
unknown |
topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Vimaleswaran, Karani S Cavadino, Alana Verweij, Niek Nolte, Ilja M Leach, Irene Mateo _, _ Auvinen, Juha Veijola, Juha Elliott, Paul Penninx, Brenda W Snieder, Harold Järvelin, Marjo-Riitta van der Harst, Pim Cohen, Robert D Boucher, Barbara J Hyppönen, Elina Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
Background and objective Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obesity and alcohol intake. To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations ( n =20 242). Design and methods The study populations included the Northern Finland Birth Cohort 1966 ( n =4996), Netherlands Study of Depression and Anxiety ( n =1883) and LifeLines Cohort Study ( n =13 363). Interactions between the polymorphisms and obesity and alcohol intake on dichotomised ALT and GGT levels were assessed using logistic regression and the likelihood ratio test. Results In the meta-analysis of the three cohorts, none of the three UCP2 polymorphisms were associated with GGT or ALT levels. There was no evidence for interaction between the polymorphisms and alcohol intake on GGT and ALT levels. In contrast, the association of WC and BMI with GGT levels varied by rs659366 genotype ( P interaction =0.03 and 0.007, respectively; adjusted for age, gender, high alcohol intake, diabetes, hypertension and serum lipid concentrations). Conclusion In conclusion, our findings in 20 242 individuals suggest that UCP2 gene polymorphisms may cause liver dysfunction through the interaction with body fat rather than alcohol intake. |
format |
Article in Journal/Newspaper |
author |
Vimaleswaran, Karani S Cavadino, Alana Verweij, Niek Nolte, Ilja M Leach, Irene Mateo _, _ Auvinen, Juha Veijola, Juha Elliott, Paul Penninx, Brenda W Snieder, Harold Järvelin, Marjo-Riitta van der Harst, Pim Cohen, Robert D Boucher, Barbara J Hyppönen, Elina |
author_facet |
Vimaleswaran, Karani S Cavadino, Alana Verweij, Niek Nolte, Ilja M Leach, Irene Mateo _, _ Auvinen, Juha Veijola, Juha Elliott, Paul Penninx, Brenda W Snieder, Harold Järvelin, Marjo-Riitta van der Harst, Pim Cohen, Robert D Boucher, Barbara J Hyppönen, Elina |
author_sort |
Vimaleswaran, Karani S |
title |
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
title_short |
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
title_full |
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
title_fullStr |
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
title_full_unstemmed |
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
title_sort |
interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study |
publisher |
Bioscientifica |
publishDate |
2015 |
url |
http://dx.doi.org/10.1530/eje-15-0839 https://eje.bioscientifica.com/view/journals/eje/173/6/863.xml |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
European Journal of Endocrinology volume 173, issue 6, page 863-872 ISSN 0804-4643 1479-683X |
op_rights |
http://creativecommons.org/licenses/by/3.0/deed.en_GB |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1530/eje-15-0839 |
container_title |
European Journal of Endocrinology |
container_volume |
173 |
container_issue |
6 |
container_start_page |
863 |
op_container_end_page |
872 |
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1766144718626881536 |