Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study
Objective To study the impact of endogenous testosterone levels in community-dwelling men on later risk for myocardial infarction (MI) and all-cause, cardiovascular disease (CVD), and ischemic heart disease (IHD) mortality. Design Population-based prospective cohort study. Methods For the analyses,...
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Online Access: | http://dx.doi.org/10.1530/eje-09-0284 https://eje.bioscientifica.com/view/journals/eje/161/3/435.xml |
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crbioscientif:10.1530/eje-09-0284 2023-05-15T18:34:29+02:00 Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study Vikan, Torkel Schirmer, Henrik Njølstad, Inger Svartberg, Johan 2009 http://dx.doi.org/10.1530/eje-09-0284 https://eje.bioscientifica.com/view/journals/eje/161/3/435.xml unknown Bioscientifica European Journal of Endocrinology volume 161, issue 3, page 435-442 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2009 crbioscientif https://doi.org/10.1530/eje-09-0284 2022-11-04T15:03:49Z Objective To study the impact of endogenous testosterone levels in community-dwelling men on later risk for myocardial infarction (MI) and all-cause, cardiovascular disease (CVD), and ischemic heart disease (IHD) mortality. Design Population-based prospective cohort study. Methods For the analyses, we used a cohort of 1568 randomly selected men, with sex-hormone data participating in the fourth Tromsø Study (1994–1995). Defined end points were first-ever MI (fatal or nonfatal), all-cause, CVD, and IHD mortality. A committee performed thorough ascertainment of end points, following a detailed protocol. Complete ascertainment of end points was until 30 September 2007 for all-cause mortality, until 31 December 2005 for CVD/IHD mortality, and until 31 December 2004 for first-ever MI. The prospective association between total and free testosterone and end points were examined using Cox proportional hazard regression, allowing for multivariate adjustment for age and cardiovascular risk factors. Results During follow-up, there were 395 deaths from all causes, 130 deaths from CVD and 80 deaths from IHD, while 144 men experienced a first-ever MI. There was a significant increase in all-cause mortality risk for men with free testosterone in the lowest quartile (<158 pmol/l) compared with the higher quartiles after age adjustment hazard ratios (HR 1.24, 95% confidence interval, CI 1.01–1.53) and after multivariate adjustments (HR 1.24, 95% CI 1.01–1.54). Total testosterone was not associated with mortality risk. Likewise, there were no significant changes in risk for first-ever MI across different total or free testosterone levels. Conclusion Men with free testosterone levels in the lowest quartile had a 24% increased risk of all-cause mortality. Article in Journal/Newspaper Tromsø Bioscientifica (via Crossref) Tromsø European Journal of Endocrinology 161 3 435 442 |
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Open Polar |
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Bioscientifica (via Crossref) |
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crbioscientif |
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unknown |
topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Vikan, Torkel Schirmer, Henrik Njølstad, Inger Svartberg, Johan Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
Objective To study the impact of endogenous testosterone levels in community-dwelling men on later risk for myocardial infarction (MI) and all-cause, cardiovascular disease (CVD), and ischemic heart disease (IHD) mortality. Design Population-based prospective cohort study. Methods For the analyses, we used a cohort of 1568 randomly selected men, with sex-hormone data participating in the fourth Tromsø Study (1994–1995). Defined end points were first-ever MI (fatal or nonfatal), all-cause, CVD, and IHD mortality. A committee performed thorough ascertainment of end points, following a detailed protocol. Complete ascertainment of end points was until 30 September 2007 for all-cause mortality, until 31 December 2005 for CVD/IHD mortality, and until 31 December 2004 for first-ever MI. The prospective association between total and free testosterone and end points were examined using Cox proportional hazard regression, allowing for multivariate adjustment for age and cardiovascular risk factors. Results During follow-up, there were 395 deaths from all causes, 130 deaths from CVD and 80 deaths from IHD, while 144 men experienced a first-ever MI. There was a significant increase in all-cause mortality risk for men with free testosterone in the lowest quartile (<158 pmol/l) compared with the higher quartiles after age adjustment hazard ratios (HR 1.24, 95% confidence interval, CI 1.01–1.53) and after multivariate adjustments (HR 1.24, 95% CI 1.01–1.54). Total testosterone was not associated with mortality risk. Likewise, there were no significant changes in risk for first-ever MI across different total or free testosterone levels. Conclusion Men with free testosterone levels in the lowest quartile had a 24% increased risk of all-cause mortality. |
format |
Article in Journal/Newspaper |
author |
Vikan, Torkel Schirmer, Henrik Njølstad, Inger Svartberg, Johan |
author_facet |
Vikan, Torkel Schirmer, Henrik Njølstad, Inger Svartberg, Johan |
author_sort |
Vikan, Torkel |
title |
Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
title_short |
Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
title_full |
Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
title_fullStr |
Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
title_full_unstemmed |
Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study |
title_sort |
endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the tromsø study |
publisher |
Bioscientifica |
publishDate |
2009 |
url |
http://dx.doi.org/10.1530/eje-09-0284 https://eje.bioscientifica.com/view/journals/eje/161/3/435.xml |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Endocrinology volume 161, issue 3, page 435-442 ISSN 0804-4643 1479-683X |
op_doi |
https://doi.org/10.1530/eje-09-0284 |
container_title |
European Journal of Endocrinology |
container_volume |
161 |
container_issue |
3 |
container_start_page |
435 |
op_container_end_page |
442 |
_version_ |
1766219248719364096 |