The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study
Objective Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy...
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crbioscientif:10.1530/ec-17-0046 2024-09-15T18:26:09+00:00 The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study Lundqvist, Anette Sandström, Herbert Bäckström, Torbjörn 2017 http://dx.doi.org/10.1530/ec-17-0046 https://ec.bioscientifica.com/view/journals/ec/6/4/253.xml https://ec.bioscientifica.com/downloadpdf/journals/ec/6/4/253.xml unknown Bioscientifica http://creativecommons.org/licenses/by-nc/4.0/ Endocrine Connections volume 6, issue 4, page 253-259 ISSN 2049-3614 journal-article 2017 crbioscientif https://doi.org/10.1530/ec-17-0046 2024-08-15T04:09:21Z Objective Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design A longitudinal, cohort study. Methods Pregnant women ( n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results Weight increase correlated significantly to allopregnanolone in late pregnancy increase ( r s = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained ≥11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased <11 kg ( P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations. Article in Journal/Newspaper Northern Sweden Bioscientifica Endocrine Connections 6 4 253 259 |
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Objective Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design A longitudinal, cohort study. Methods Pregnant women ( n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results Weight increase correlated significantly to allopregnanolone in late pregnancy increase ( r s = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained ≥11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased <11 kg ( P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations. |
format |
Article in Journal/Newspaper |
author |
Lundqvist, Anette Sandström, Herbert Bäckström, Torbjörn |
spellingShingle |
Lundqvist, Anette Sandström, Herbert Bäckström, Torbjörn The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
author_facet |
Lundqvist, Anette Sandström, Herbert Bäckström, Torbjörn |
author_sort |
Lundqvist, Anette |
title |
The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
title_short |
The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
title_full |
The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
title_fullStr |
The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
title_full_unstemmed |
The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
title_sort |
relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
publisher |
Bioscientifica |
publishDate |
2017 |
url |
http://dx.doi.org/10.1530/ec-17-0046 https://ec.bioscientifica.com/view/journals/ec/6/4/253.xml https://ec.bioscientifica.com/downloadpdf/journals/ec/6/4/253.xml |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Endocrine Connections volume 6, issue 4, page 253-259 ISSN 2049-3614 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1530/ec-17-0046 |
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Endocrine Connections |
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6 |
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4 |
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253 |
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259 |
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1810466604538920960 |