Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2
Background:: Filamentous fungi in the genus Aspergillus are well known for their important roles in production of bioactive secondary metabolites with diversely chemical structures and potential application in pharmaceutical industry. Objective:: The present study aimed to investigate the phenolic b...
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2024
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Online Access: | http://dx.doi.org/10.2174/0122103155279752240104050411 https://www.eurekaselect.com/article/download?doi=10.2174/0122103155279752240104050411 https://www.eurekaselect.com/226350/article |
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crbenthamsciepub:10.2174/0122103155279752240104050411 2024-09-09T19:21:24+00:00 Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 Fu, Zhiyang Gong, Xiangzhou Hu, Zhe Zhao, Yujie Zhang, Huawei National Key Research and Development Program of China 2024 http://dx.doi.org/10.2174/0122103155279752240104050411 https://www.eurekaselect.com/article/download?doi=10.2174/0122103155279752240104050411 https://www.eurekaselect.com/226350/article en eng Bentham Science Publishers Ltd. The Natural Products Journal volume 14, issue 7 ISSN 2210-3155 journal-article 2024 crbenthamsciepub https://doi.org/10.2174/0122103155279752240104050411 2024-08-01T04:09:42Z Background:: Filamentous fungi in the genus Aspergillus are well known for their important roles in production of bioactive secondary metabolites with diversely chemical structures and potential application in pharmaceutical industry. Objective:: The present study aimed to investigate the phenolic bisabolane sesquiterpene (PBS) derivatives from an Arctic marine-derived fungus Aspergillus sydowii MNP-2. Methods:: In this study, antimicrobial activities were carried out according to the broth microdilution assay, nitric oxide (NO) production in mouse macrophages (RAW264.7) and BV2 microglial cells was used to detect the inhibitory effect of compounds in inflammatory reactions, and in vitro inhibitory cell proliferation activity was determined by the cell counting kit-8 (CCK-8) assay. Results:: In this work, chemical investigation of an Arctic marine-derived strain A. sydowii MNP-2 led to the isolation of 11 PBSs (1-11) using various chromatographic methods. Their chemical structures were unambiguously determined by 1H NMR spectroscopy and mass spectrometry analyses as well as comparison with literature data. It is noteworthy that compounds 1, 7 and 11 were firstly obtained from A. sydowii. Antimicrobial assay showed that these chemicals had no potent inhibitory effect on Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values > 16 μg/mL. Additionally, the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)- induced inflammation in mouse macrophages (RAW264.7) and BV2 microglial cells were all below 10% for compounds 4-6 and 8, indicating almost negligible anti-inflammatory efficacy. Among the tested compounds 4-6 and 8 for tumor-cell proliferation inhibition activities, compound 5 demonstrated the strongest inhibitory effect against human acute promyelocytic leukemia cells (HL-6) with a 44.76% inhibition rate. Conclusion:: In the present study, 11 PBS derivatives were purified and characterized from the solidand liquid-state fermentations of the Arctic marine-derived ... Article in Journal/Newspaper Arctic Bentham Science Publishers Arctic The Natural Products Journal 14 |
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Open Polar |
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Bentham Science Publishers |
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crbenthamsciepub |
language |
English |
description |
Background:: Filamentous fungi in the genus Aspergillus are well known for their important roles in production of bioactive secondary metabolites with diversely chemical structures and potential application in pharmaceutical industry. Objective:: The present study aimed to investigate the phenolic bisabolane sesquiterpene (PBS) derivatives from an Arctic marine-derived fungus Aspergillus sydowii MNP-2. Methods:: In this study, antimicrobial activities were carried out according to the broth microdilution assay, nitric oxide (NO) production in mouse macrophages (RAW264.7) and BV2 microglial cells was used to detect the inhibitory effect of compounds in inflammatory reactions, and in vitro inhibitory cell proliferation activity was determined by the cell counting kit-8 (CCK-8) assay. Results:: In this work, chemical investigation of an Arctic marine-derived strain A. sydowii MNP-2 led to the isolation of 11 PBSs (1-11) using various chromatographic methods. Their chemical structures were unambiguously determined by 1H NMR spectroscopy and mass spectrometry analyses as well as comparison with literature data. It is noteworthy that compounds 1, 7 and 11 were firstly obtained from A. sydowii. Antimicrobial assay showed that these chemicals had no potent inhibitory effect on Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values > 16 μg/mL. Additionally, the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)- induced inflammation in mouse macrophages (RAW264.7) and BV2 microglial cells were all below 10% for compounds 4-6 and 8, indicating almost negligible anti-inflammatory efficacy. Among the tested compounds 4-6 and 8 for tumor-cell proliferation inhibition activities, compound 5 demonstrated the strongest inhibitory effect against human acute promyelocytic leukemia cells (HL-6) with a 44.76% inhibition rate. Conclusion:: In the present study, 11 PBS derivatives were purified and characterized from the solidand liquid-state fermentations of the Arctic marine-derived ... |
author2 |
National Key Research and Development Program of China |
format |
Article in Journal/Newspaper |
author |
Fu, Zhiyang Gong, Xiangzhou Hu, Zhe Zhao, Yujie Zhang, Huawei |
spellingShingle |
Fu, Zhiyang Gong, Xiangzhou Hu, Zhe Zhao, Yujie Zhang, Huawei Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
author_facet |
Fu, Zhiyang Gong, Xiangzhou Hu, Zhe Zhao, Yujie Zhang, Huawei |
author_sort |
Fu, Zhiyang |
title |
Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
title_short |
Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
title_full |
Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
title_fullStr |
Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
title_full_unstemmed |
Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived Fungus Aspergillus sydowii MNP-2 |
title_sort |
phenolic bisabolane sesquiterpene derivatives from an arctic marine-derived fungus aspergillus sydowii mnp-2 |
publisher |
Bentham Science Publishers Ltd. |
publishDate |
2024 |
url |
http://dx.doi.org/10.2174/0122103155279752240104050411 https://www.eurekaselect.com/article/download?doi=10.2174/0122103155279752240104050411 https://www.eurekaselect.com/226350/article |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
The Natural Products Journal volume 14, issue 7 ISSN 2210-3155 |
op_doi |
https://doi.org/10.2174/0122103155279752240104050411 |
container_title |
The Natural Products Journal |
container_volume |
14 |
_version_ |
1809761607658504192 |