Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica
ABSTRACT Distinct lineages of avian influenza viruses (AIVs) are harbored by spatially segregated birds, yet significant surveillance gaps exist around the globe. Virtually nothing is known from the Antarctic. Using virus culture, molecular analysis, full genome sequencing, and serology of samples f...
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Online Access: | http://dx.doi.org/10.1128/mbio.01098-14 https://journals.asm.org/doi/pdf/10.1128/mBio.01098-14 |
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crasmicro:10.1128/mbio.01098-14 2024-06-23T07:46:00+00:00 Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica Hurt, Aeron C. Vijaykrishna, Dhanasekaran Butler, Jeffrey Baas, Chantal Maurer-Stroh, Sebastian Silva-de-la-Fuente, M. Carolina Medina-Vogel, Gonzalo Olsen, Bjorn Kelso, Anne Barr, Ian G. González-Acuña, Daniel Perez, Daniel Meng, Xiang-Jin 2014 http://dx.doi.org/10.1128/mbio.01098-14 https://journals.asm.org/doi/pdf/10.1128/mBio.01098-14 en eng American Society for Microbiology http://creativecommons.org/licenses/by-nc-sa/3.0/ https://journals.asm.org/non-commercial-tdm-license mBio volume 5, issue 3 ISSN 2161-2129 2150-7511 journal-article 2014 crasmicro https://doi.org/10.1128/mbio.01098-14 2024-05-27T12:59:59Z ABSTRACT Distinct lineages of avian influenza viruses (AIVs) are harbored by spatially segregated birds, yet significant surveillance gaps exist around the globe. Virtually nothing is known from the Antarctic. Using virus culture, molecular analysis, full genome sequencing, and serology of samples from Adélie penguins in Antarctica, we confirmed infection by H11N2 subtype AIVs. Their genetic segments were distinct from all known contemporary influenza viruses, including South American AIVs, suggesting spatial separation from other lineages. Only in the matrix and polymerase acidic gene phylogenies did the Antarctic sequences form a sister relationship to South American AIVs, whereas distant phylogenetic relationships were evident in all other gene segments. Interestingly, their neuraminidase genes formed a distant relationship to all avian and human influenza lineages, and the polymerase basic 1 and polymerase acidic formed a sister relationship to the equine H3N8 influenza virus lineage that emerged during 1963 and whose avian origins were previously unknown. We also estimated that each gene segment had diverged for 49 to 80 years from its most closely related sequences, highlighting a significant gap in our AIV knowledge in the region. We also show that the receptor binding properties of the H11N2 viruses are predominantly avian and that they were unable to replicate efficiently in experimentally inoculated ferrets, suggesting their continuous evolution in avian hosts. These findings add substantially to our understanding of both the ecology and the intra- and intercontinental movement of Antarctic AIVs and highlight the potential risk of an incursion of highly pathogenic AIVs into this fragile environment. IMPORTANCE Avian influenza viruses (AIVs) are typically maintained and spread by migratory birds, resulting in the existence of distinctly different viruses around the world. However, AIVs have not previously been detected in Antarctica. In this study, we characterized H11N2 viruses sampled from Adélie ... Article in Journal/Newspaper Antarc* Antarctic Antarctica ASM Journals (American Society for Microbiology) Antarctic The Antarctic mBio 5 3 |
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Open Polar |
collection |
ASM Journals (American Society for Microbiology) |
op_collection_id |
crasmicro |
language |
English |
description |
ABSTRACT Distinct lineages of avian influenza viruses (AIVs) are harbored by spatially segregated birds, yet significant surveillance gaps exist around the globe. Virtually nothing is known from the Antarctic. Using virus culture, molecular analysis, full genome sequencing, and serology of samples from Adélie penguins in Antarctica, we confirmed infection by H11N2 subtype AIVs. Their genetic segments were distinct from all known contemporary influenza viruses, including South American AIVs, suggesting spatial separation from other lineages. Only in the matrix and polymerase acidic gene phylogenies did the Antarctic sequences form a sister relationship to South American AIVs, whereas distant phylogenetic relationships were evident in all other gene segments. Interestingly, their neuraminidase genes formed a distant relationship to all avian and human influenza lineages, and the polymerase basic 1 and polymerase acidic formed a sister relationship to the equine H3N8 influenza virus lineage that emerged during 1963 and whose avian origins were previously unknown. We also estimated that each gene segment had diverged for 49 to 80 years from its most closely related sequences, highlighting a significant gap in our AIV knowledge in the region. We also show that the receptor binding properties of the H11N2 viruses are predominantly avian and that they were unable to replicate efficiently in experimentally inoculated ferrets, suggesting their continuous evolution in avian hosts. These findings add substantially to our understanding of both the ecology and the intra- and intercontinental movement of Antarctic AIVs and highlight the potential risk of an incursion of highly pathogenic AIVs into this fragile environment. IMPORTANCE Avian influenza viruses (AIVs) are typically maintained and spread by migratory birds, resulting in the existence of distinctly different viruses around the world. However, AIVs have not previously been detected in Antarctica. In this study, we characterized H11N2 viruses sampled from Adélie ... |
author2 |
Perez, Daniel Meng, Xiang-Jin |
format |
Article in Journal/Newspaper |
author |
Hurt, Aeron C. Vijaykrishna, Dhanasekaran Butler, Jeffrey Baas, Chantal Maurer-Stroh, Sebastian Silva-de-la-Fuente, M. Carolina Medina-Vogel, Gonzalo Olsen, Bjorn Kelso, Anne Barr, Ian G. González-Acuña, Daniel |
spellingShingle |
Hurt, Aeron C. Vijaykrishna, Dhanasekaran Butler, Jeffrey Baas, Chantal Maurer-Stroh, Sebastian Silva-de-la-Fuente, M. Carolina Medina-Vogel, Gonzalo Olsen, Bjorn Kelso, Anne Barr, Ian G. González-Acuña, Daniel Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
author_facet |
Hurt, Aeron C. Vijaykrishna, Dhanasekaran Butler, Jeffrey Baas, Chantal Maurer-Stroh, Sebastian Silva-de-la-Fuente, M. Carolina Medina-Vogel, Gonzalo Olsen, Bjorn Kelso, Anne Barr, Ian G. González-Acuña, Daniel |
author_sort |
Hurt, Aeron C. |
title |
Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
title_short |
Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
title_full |
Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
title_fullStr |
Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
title_full_unstemmed |
Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica |
title_sort |
detection of evolutionarily distinct avian influenza a viruses in antarctica |
publisher |
American Society for Microbiology |
publishDate |
2014 |
url |
http://dx.doi.org/10.1128/mbio.01098-14 https://journals.asm.org/doi/pdf/10.1128/mBio.01098-14 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
mBio volume 5, issue 3 ISSN 2161-2129 2150-7511 |
op_rights |
http://creativecommons.org/licenses/by-nc-sa/3.0/ https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/mbio.01098-14 |
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mBio |
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5 |
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3 |
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1802643484852617216 |