Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas
ABSTRACT A novel piscine retrovirus has been identified in association with an outbreak of leiomyosarcoma in the swim bladders of Atlantic salmon. The complete nucleotide sequence of the Atlantic salmon swim bladder sarcoma virus (SSSV) provirus is 10.9 kb in length and shares a structure and transc...
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crasmicro:10.1128/jvi.80.6.2941-2948.2006 2024-10-06T13:47:13+00:00 Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas Paul, Thomas A. Quackenbush, Sandra L. Sutton, Claudia Casey, Rufina N. Bowser, Paul R. Casey, James W. 2006 http://dx.doi.org/10.1128/jvi.80.6.2941-2948.2006 https://journals.asm.org/doi/pdf/10.1128/JVI.80.6.2941-2948.2006 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Journal of Virology volume 80, issue 6, page 2941-2948 ISSN 0022-538X 1098-5514 journal-article 2006 crasmicro https://doi.org/10.1128/jvi.80.6.2941-2948.2006 2024-09-09T04:16:36Z ABSTRACT A novel piscine retrovirus has been identified in association with an outbreak of leiomyosarcoma in the swim bladders of Atlantic salmon. The complete nucleotide sequence of the Atlantic salmon swim bladder sarcoma virus (SSSV) provirus is 10.9 kb in length and shares a structure and transcriptional profile similar to those of murine leukemia virus-like simple retroviruses. SSSV appears unique to simple retroviruses by not harboring sequences in the Atlantic salmon genome. Additionally, SSSV differs from other retroviruses in potentially utilizing a methionine tRNA primer binding site. SSSV-associated tumors contain high proviral copy numbers (greater than 30 per cell) and a polyclonal integration pattern. Phylogenetic analysis based on reverse transcriptase places SSSV with zebrafish endogenous retrovirus (ZFERV) between the Gammaretrovirus and Epsilonretrovirus genera. Large regions of continuous homology between SSSV and ZFERV Gag, Pol, and Env suggest that these viruses represent a new group of related piscine retroviruses. Article in Journal/Newspaper Atlantic salmon ASM Journals (American Society for Microbiology) Journal of Virology 80 6 2941 2948 |
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Open Polar |
collection |
ASM Journals (American Society for Microbiology) |
op_collection_id |
crasmicro |
language |
English |
description |
ABSTRACT A novel piscine retrovirus has been identified in association with an outbreak of leiomyosarcoma in the swim bladders of Atlantic salmon. The complete nucleotide sequence of the Atlantic salmon swim bladder sarcoma virus (SSSV) provirus is 10.9 kb in length and shares a structure and transcriptional profile similar to those of murine leukemia virus-like simple retroviruses. SSSV appears unique to simple retroviruses by not harboring sequences in the Atlantic salmon genome. Additionally, SSSV differs from other retroviruses in potentially utilizing a methionine tRNA primer binding site. SSSV-associated tumors contain high proviral copy numbers (greater than 30 per cell) and a polyclonal integration pattern. Phylogenetic analysis based on reverse transcriptase places SSSV with zebrafish endogenous retrovirus (ZFERV) between the Gammaretrovirus and Epsilonretrovirus genera. Large regions of continuous homology between SSSV and ZFERV Gag, Pol, and Env suggest that these viruses represent a new group of related piscine retroviruses. |
format |
Article in Journal/Newspaper |
author |
Paul, Thomas A. Quackenbush, Sandra L. Sutton, Claudia Casey, Rufina N. Bowser, Paul R. Casey, James W. |
spellingShingle |
Paul, Thomas A. Quackenbush, Sandra L. Sutton, Claudia Casey, Rufina N. Bowser, Paul R. Casey, James W. Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
author_facet |
Paul, Thomas A. Quackenbush, Sandra L. Sutton, Claudia Casey, Rufina N. Bowser, Paul R. Casey, James W. |
author_sort |
Paul, Thomas A. |
title |
Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
title_short |
Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
title_full |
Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
title_fullStr |
Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
title_full_unstemmed |
Identification and Characterization of an Exogenous Retrovirus from Atlantic Salmon Swim Bladder Sarcomas |
title_sort |
identification and characterization of an exogenous retrovirus from atlantic salmon swim bladder sarcomas |
publisher |
American Society for Microbiology |
publishDate |
2006 |
url |
http://dx.doi.org/10.1128/jvi.80.6.2941-2948.2006 https://journals.asm.org/doi/pdf/10.1128/JVI.80.6.2941-2948.2006 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Journal of Virology volume 80, issue 6, page 2941-2948 ISSN 0022-538X 1098-5514 |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/jvi.80.6.2941-2948.2006 |
container_title |
Journal of Virology |
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80 |
container_issue |
6 |
container_start_page |
2941 |
op_container_end_page |
2948 |
_version_ |
1812175455747309568 |