Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase

Monoclonal antibodies which inhibit influenza virus neuraminidase (NA) and which therefore indirectly neutralize virus infectivity bind to epitopes located on the rim of the active-site crater. The three-dimensional structure of one of these epitopes, recognized by monoclonal antibody NC41, has prev...

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Bibliographic Details
Published in:Journal of Virology
Main Authors: Air, G M, Laver, W G, Webster, R G
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 1990
Subjects:
Online Access:http://dx.doi.org/10.1128/jvi.64.12.5797-5803.1990
https://journals.asm.org/doi/pdf/10.1128/jvi.64.12.5797-5803.1990