Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls
ABSTRACT Infections of domestic and wild birds with low-pathogenic avian influenza viruses (LPAIVs) have been associated with protective immunity to subsequent infection. However, the degree and duration of immunity in wild birds from previous LPAIV infection, by the same or a different subtype, are...
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Online Access: | http://dx.doi.org/10.1128/jvi.01765-15 https://journals.asm.org/doi/pdf/10.1128/JVI.01765-15 |
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crasmicro:10.1128/jvi.01765-15 2024-04-07T07:56:30+00:00 Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls Verhagen, Josanne H. Höfle, Ursula van Amerongen, Geert van de Bildt, Marco Majoor, Frank Fouchier, Ron A. M. Kuiken, Thijs Schultz-Cherry, S. 2015 http://dx.doi.org/10.1128/jvi.01765-15 https://journals.asm.org/doi/pdf/10.1128/JVI.01765-15 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Journal of Virology volume 89, issue 22, page 11507-11522 ISSN 0022-538X 1098-5514 Virology Insect Science Immunology Microbiology journal-article 2015 crasmicro https://doi.org/10.1128/jvi.01765-15 2024-03-08T00:24:26Z ABSTRACT Infections of domestic and wild birds with low-pathogenic avian influenza viruses (LPAIVs) have been associated with protective immunity to subsequent infection. However, the degree and duration of immunity in wild birds from previous LPAIV infection, by the same or a different subtype, are poorly understood. Therefore, we inoculated H13N2 (A/black-headed gull/Netherlands/7/2009) and H16N3 (A/black-headed gull/Netherlands/26/2009) LPAIVs into black-headed gulls ( Chroicocephalus ridibundus ), their natural host species, and measured the long-term immune response and protection against one or two reinfections over a period of >1 year. This is the typical interval between LPAIV epizootics in wild birds. Reinfection with the same virus resulted in progressively less virus excretion, with complete abrogation of virus excretion after two infections for H13 but not H16. However, reinfection with the other virus affected neither the level nor duration of virus excretion. Virus excretion by immunologically naive birds did not differ in total levels of excreted H13 or H16 virus between first- and second-year birds, but the duration of H13 excretion was shorter for second-year birds. Furthermore, serum antibody levels did not correlate with protection against LPAIV infection. LPAIV-infected gulls showed no clinical signs of disease. These results imply that the epidemiological cycles of H13 and H16 in black-headed gulls are relatively independent from each other and depend mainly on infection of first-year birds. IMPORTANCE Low-pathogenic avian influenza viruses (LPAIVs) circulate mainly in wild water birds but are occasionally transmitted to other species, including humans, where they cause subclinical to fatal disease. To date, the effect of LPAIV-specific immunity on the epidemiology of LPAIV in wild birds is poorly understood. In this study, we investigated the effect of H13 and H16 LPAIV infection in black-headed gulls on susceptibility and virus excretion of subsequent infection with the same or the ... Article in Journal/Newspaper Black-headed Gull Chroicocephalus ridibundus ASM Journals (American Society for Microbiology) Journal of Virology 89 22 11507 11522 |
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Open Polar |
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ASM Journals (American Society for Microbiology) |
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crasmicro |
language |
English |
topic |
Virology Insect Science Immunology Microbiology |
spellingShingle |
Virology Insect Science Immunology Microbiology Verhagen, Josanne H. Höfle, Ursula van Amerongen, Geert van de Bildt, Marco Majoor, Frank Fouchier, Ron A. M. Kuiken, Thijs Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
topic_facet |
Virology Insect Science Immunology Microbiology |
description |
ABSTRACT Infections of domestic and wild birds with low-pathogenic avian influenza viruses (LPAIVs) have been associated with protective immunity to subsequent infection. However, the degree and duration of immunity in wild birds from previous LPAIV infection, by the same or a different subtype, are poorly understood. Therefore, we inoculated H13N2 (A/black-headed gull/Netherlands/7/2009) and H16N3 (A/black-headed gull/Netherlands/26/2009) LPAIVs into black-headed gulls ( Chroicocephalus ridibundus ), their natural host species, and measured the long-term immune response and protection against one or two reinfections over a period of >1 year. This is the typical interval between LPAIV epizootics in wild birds. Reinfection with the same virus resulted in progressively less virus excretion, with complete abrogation of virus excretion after two infections for H13 but not H16. However, reinfection with the other virus affected neither the level nor duration of virus excretion. Virus excretion by immunologically naive birds did not differ in total levels of excreted H13 or H16 virus between first- and second-year birds, but the duration of H13 excretion was shorter for second-year birds. Furthermore, serum antibody levels did not correlate with protection against LPAIV infection. LPAIV-infected gulls showed no clinical signs of disease. These results imply that the epidemiological cycles of H13 and H16 in black-headed gulls are relatively independent from each other and depend mainly on infection of first-year birds. IMPORTANCE Low-pathogenic avian influenza viruses (LPAIVs) circulate mainly in wild water birds but are occasionally transmitted to other species, including humans, where they cause subclinical to fatal disease. To date, the effect of LPAIV-specific immunity on the epidemiology of LPAIV in wild birds is poorly understood. In this study, we investigated the effect of H13 and H16 LPAIV infection in black-headed gulls on susceptibility and virus excretion of subsequent infection with the same or the ... |
author2 |
Schultz-Cherry, S. |
format |
Article in Journal/Newspaper |
author |
Verhagen, Josanne H. Höfle, Ursula van Amerongen, Geert van de Bildt, Marco Majoor, Frank Fouchier, Ron A. M. Kuiken, Thijs |
author_facet |
Verhagen, Josanne H. Höfle, Ursula van Amerongen, Geert van de Bildt, Marco Majoor, Frank Fouchier, Ron A. M. Kuiken, Thijs |
author_sort |
Verhagen, Josanne H. |
title |
Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
title_short |
Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
title_full |
Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
title_fullStr |
Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
title_full_unstemmed |
Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls |
title_sort |
long-term effect of serial infections with h13 and h16 low-pathogenic avian influenza viruses in black-headed gulls |
publisher |
American Society for Microbiology |
publishDate |
2015 |
url |
http://dx.doi.org/10.1128/jvi.01765-15 https://journals.asm.org/doi/pdf/10.1128/JVI.01765-15 |
genre |
Black-headed Gull Chroicocephalus ridibundus |
genre_facet |
Black-headed Gull Chroicocephalus ridibundus |
op_source |
Journal of Virology volume 89, issue 22, page 11507-11522 ISSN 0022-538X 1098-5514 |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/jvi.01765-15 |
container_title |
Journal of Virology |
container_volume |
89 |
container_issue |
22 |
container_start_page |
11507 |
op_container_end_page |
11522 |
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1795674436686315520 |