Extensive Host Sharing of Central European Tula Virus
ABSTRACT To examine the host association of Tula virus (TULV), a hantavirus present in large parts of Europe, we investigated a total of 791 rodents representing 469 Microtus arvalis and 322 Microtus agrestis animals from northeast, northwest, and southeast Germany, including geographical regions wi...
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crasmicro:10.1128/jvi.01226-09 2024-06-23T07:54:38+00:00 Extensive Host Sharing of Central European Tula Virus Schmidt-Chanasit, Jonas Essbauer, Sandra Petraityte, Rasa Yoshimatsu, Kumiko Tackmann, Kirsten Conraths, Franz J. Sasnauskas, Kestutis Arikawa, Jiro Thomas, Astrid Pfeffer, Martin Scharninghausen, Jerrold J. Splettstoesser, Wolf Wenk, Matthias Heckel, Gerald Ulrich, Rainer G. 2010 http://dx.doi.org/10.1128/jvi.01226-09 https://journals.asm.org/doi/pdf/10.1128/JVI.01226-09 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Journal of Virology volume 84, issue 1, page 459-474 ISSN 0022-538X 1098-5514 journal-article 2010 crasmicro https://doi.org/10.1128/jvi.01226-09 2024-06-03T08:10:38Z ABSTRACT To examine the host association of Tula virus (TULV), a hantavirus present in large parts of Europe, we investigated a total of 791 rodents representing 469 Microtus arvalis and 322 Microtus agrestis animals from northeast, northwest, and southeast Germany, including geographical regions with sympatric occurrence of both vole species, for the presence of TULV infections. Based on serological investigation, reverse transcriptase PCR, and subsequent sequence analysis of partial small (S) and medium (M) segments, we herein show that TULV is carried not only by its commonly known host M. arvalis but also frequently by M. agrestis in different regions of Germany for a prolonged time period. At one trapping site, TULV was exclusively detected in M. agrestis , suggesting an isolated transmission cycle in this rodent reservoir separate from spillover infections of TULV-carrying M. arvalis . Phylogenetic analysis of the S and M segment sequences demonstrated geographical clustering of the TULV sequences irrespective of the host, M. arvalis or M. agrestis . The novel TULV lineages from northeast, northwest, and southeast Germany described here are clearly separated from each other and from other German, European, or Asian lineages, suggesting their stable geographical localization and fast sequence evolution. In conclusion, these results demonstrate that TULV represents a promiscuous hantavirus with a large panel of susceptible hosts. In addition, this may suggest an alternative evolution mode, other than a strict coevolution, for this virus in its Microtus hosts, which should be proven in further large-scale investigations on sympatric Microtus hosts. Article in Journal/Newspaper Microtus arvalis ASM Journals (American Society for Microbiology) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Journal of Virology 84 1 459 474 |
institution |
Open Polar |
collection |
ASM Journals (American Society for Microbiology) |
op_collection_id |
crasmicro |
language |
English |
description |
ABSTRACT To examine the host association of Tula virus (TULV), a hantavirus present in large parts of Europe, we investigated a total of 791 rodents representing 469 Microtus arvalis and 322 Microtus agrestis animals from northeast, northwest, and southeast Germany, including geographical regions with sympatric occurrence of both vole species, for the presence of TULV infections. Based on serological investigation, reverse transcriptase PCR, and subsequent sequence analysis of partial small (S) and medium (M) segments, we herein show that TULV is carried not only by its commonly known host M. arvalis but also frequently by M. agrestis in different regions of Germany for a prolonged time period. At one trapping site, TULV was exclusively detected in M. agrestis , suggesting an isolated transmission cycle in this rodent reservoir separate from spillover infections of TULV-carrying M. arvalis . Phylogenetic analysis of the S and M segment sequences demonstrated geographical clustering of the TULV sequences irrespective of the host, M. arvalis or M. agrestis . The novel TULV lineages from northeast, northwest, and southeast Germany described here are clearly separated from each other and from other German, European, or Asian lineages, suggesting their stable geographical localization and fast sequence evolution. In conclusion, these results demonstrate that TULV represents a promiscuous hantavirus with a large panel of susceptible hosts. In addition, this may suggest an alternative evolution mode, other than a strict coevolution, for this virus in its Microtus hosts, which should be proven in further large-scale investigations on sympatric Microtus hosts. |
format |
Article in Journal/Newspaper |
author |
Schmidt-Chanasit, Jonas Essbauer, Sandra Petraityte, Rasa Yoshimatsu, Kumiko Tackmann, Kirsten Conraths, Franz J. Sasnauskas, Kestutis Arikawa, Jiro Thomas, Astrid Pfeffer, Martin Scharninghausen, Jerrold J. Splettstoesser, Wolf Wenk, Matthias Heckel, Gerald Ulrich, Rainer G. |
spellingShingle |
Schmidt-Chanasit, Jonas Essbauer, Sandra Petraityte, Rasa Yoshimatsu, Kumiko Tackmann, Kirsten Conraths, Franz J. Sasnauskas, Kestutis Arikawa, Jiro Thomas, Astrid Pfeffer, Martin Scharninghausen, Jerrold J. Splettstoesser, Wolf Wenk, Matthias Heckel, Gerald Ulrich, Rainer G. Extensive Host Sharing of Central European Tula Virus |
author_facet |
Schmidt-Chanasit, Jonas Essbauer, Sandra Petraityte, Rasa Yoshimatsu, Kumiko Tackmann, Kirsten Conraths, Franz J. Sasnauskas, Kestutis Arikawa, Jiro Thomas, Astrid Pfeffer, Martin Scharninghausen, Jerrold J. Splettstoesser, Wolf Wenk, Matthias Heckel, Gerald Ulrich, Rainer G. |
author_sort |
Schmidt-Chanasit, Jonas |
title |
Extensive Host Sharing of Central European Tula Virus |
title_short |
Extensive Host Sharing of Central European Tula Virus |
title_full |
Extensive Host Sharing of Central European Tula Virus |
title_fullStr |
Extensive Host Sharing of Central European Tula Virus |
title_full_unstemmed |
Extensive Host Sharing of Central European Tula Virus |
title_sort |
extensive host sharing of central european tula virus |
publisher |
American Society for Microbiology |
publishDate |
2010 |
url |
http://dx.doi.org/10.1128/jvi.01226-09 https://journals.asm.org/doi/pdf/10.1128/JVI.01226-09 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Journal of Virology volume 84, issue 1, page 459-474 ISSN 0022-538X 1098-5514 |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/jvi.01226-09 |
container_title |
Journal of Virology |
container_volume |
84 |
container_issue |
1 |
container_start_page |
459 |
op_container_end_page |
474 |
_version_ |
1802646851682304000 |