Respiratory Tract Explant Infection Dynamics of Influenza A Virus in California Sea Lions, Northern Elephant Seals, and Rhesus Macaques

Although influenza A virus can infect marine mammals, a dearth of marine mammal cell lines and ethical and logistical challenges prohibiting experimental infections of living marine mammals mean that little is known about IAV infection kinetics in these species. We circumvented these limitations by...

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Bibliographic Details
Published in:Journal of Virology
Main Authors: Liu, Hongwei, Plancarte, Magdalena, Ball, Erin E., Weiss, Christopher M., Gonzales-Viera, Omar, Holcomb, Karen, Ma, Zhong-Min, Allen, A. Mark, Reader, J. Rachel, Duignan, Pádraig J., Halaska, Barbie, Khan, Zenab, Kriti, Divya, Dutta, Jayeeta, van Bakel, Harm, Jackson, Kenneth, Pesavento, Patricia A., Boyce, Walter M., Coffey, Lark L.
Other Authors: Parrish, Colin R., HHS | National Institutes of Health
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 2021
Subjects:
Virology
Insect Science
Immunology
Microbiology
Elephant Seals
Online Access:http://dx.doi.org/10.1128/jvi.00403-21
https://journals.asm.org/doi/pdf/10.1128/JVI.00403-21
Description
Summary:Although influenza A virus can infect marine mammals, a dearth of marine mammal cell lines and ethical and logistical challenges prohibiting experimental infections of living marine mammals mean that little is known about IAV infection kinetics in these species. We circumvented these limitations by adapting a respiratory tract explant model first to establish the approach with rhesus macaques and then for use with explants from wild marine mammals euthanized for nonrespiratory medical conditions.

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