Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates
ABSTRACT Hantavirus species Tula (TULV) is carried by European common voles ( Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became ill with fever, renal syndrome, and pneumonia. Typing of late acute- and convalescent-phase s...
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crasmicro:10.1128/jcm.41.10.4894-4897.2003 2024-04-07T07:54:03+00:00 Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates Klempa, Boris Meisel, Helga Räth, Silvana Bartel, Jan Ulrich, Rainer Krüger, Detlev H. 2003 http://dx.doi.org/10.1128/jcm.41.10.4894-4897.2003 https://journals.asm.org/doi/pdf/10.1128/JCM.41.10.4894-4897.2003 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Journal of Clinical Microbiology volume 41, issue 10, page 4894-4897 ISSN 0095-1137 1098-660X Microbiology (medical) journal-article 2003 crasmicro https://doi.org/10.1128/jcm.41.10.4894-4897.2003 2024-03-08T00:22:54Z ABSTRACT Hantavirus species Tula (TULV) is carried by European common voles ( Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became ill with fever, renal syndrome, and pneumonia. Typing of late acute- and convalescent-phase sera by focus reduction neutralization assay revealed the presence of neutralizing antibodies against TULV. Moreover, we detected TULV genetic material in Microtus arvalis animals that were trapped at places only a few kilometers from the home village of the patient. Phylogenetic analysis of completely sequenced genomic S segments from three virus strains grouped them within a third genetic lineage of the TULV species. This is the first case of hemorrhagic fever with renal syndrome and pulmonary involvement which can be associated with TULV infection. Article in Journal/Newspaper Microtus arvalis ASM Journals (American Society for Microbiology) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Journal of Clinical Microbiology 41 10 4894 4897 |
institution |
Open Polar |
collection |
ASM Journals (American Society for Microbiology) |
op_collection_id |
crasmicro |
language |
English |
topic |
Microbiology (medical) |
spellingShingle |
Microbiology (medical) Klempa, Boris Meisel, Helga Räth, Silvana Bartel, Jan Ulrich, Rainer Krüger, Detlev H. Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
topic_facet |
Microbiology (medical) |
description |
ABSTRACT Hantavirus species Tula (TULV) is carried by European common voles ( Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became ill with fever, renal syndrome, and pneumonia. Typing of late acute- and convalescent-phase sera by focus reduction neutralization assay revealed the presence of neutralizing antibodies against TULV. Moreover, we detected TULV genetic material in Microtus arvalis animals that were trapped at places only a few kilometers from the home village of the patient. Phylogenetic analysis of completely sequenced genomic S segments from three virus strains grouped them within a third genetic lineage of the TULV species. This is the first case of hemorrhagic fever with renal syndrome and pulmonary involvement which can be associated with TULV infection. |
format |
Article in Journal/Newspaper |
author |
Klempa, Boris Meisel, Helga Räth, Silvana Bartel, Jan Ulrich, Rainer Krüger, Detlev H. |
author_facet |
Klempa, Boris Meisel, Helga Räth, Silvana Bartel, Jan Ulrich, Rainer Krüger, Detlev H. |
author_sort |
Klempa, Boris |
title |
Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
title_short |
Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
title_full |
Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
title_fullStr |
Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
title_full_unstemmed |
Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates |
title_sort |
occurrence of renal and pulmonary syndrome in a region of northeast germany where tula hantavirus circulates |
publisher |
American Society for Microbiology |
publishDate |
2003 |
url |
http://dx.doi.org/10.1128/jcm.41.10.4894-4897.2003 https://journals.asm.org/doi/pdf/10.1128/JCM.41.10.4894-4897.2003 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Journal of Clinical Microbiology volume 41, issue 10, page 4894-4897 ISSN 0095-1137 1098-660X |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/jcm.41.10.4894-4897.2003 |
container_title |
Journal of Clinical Microbiology |
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41 |
container_issue |
10 |
container_start_page |
4894 |
op_container_end_page |
4897 |
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1795670334181998592 |