Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece
ABSTRACT Since January 1996, and over a 3-year time span, a significant spread of serotype 6B multidrug-resistant (MDR) pneumococci, susceptible to penicillin and resistant to erythromycin, clindamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole, was noted in young carriers liv...
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crasmicro:10.1128/jcm.39.2.581-585.2001 2023-11-05T03:42:56+01:00 Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece Syrogiannopoulos, G. A. Bogaert, D. Grivea, I. N. Beratis, N. G. De Groot, R. Hermans, P. W. M. 2001 http://dx.doi.org/10.1128/jcm.39.2.581-585.2001 https://journals.asm.org/doi/pdf/10.1128/JCM.39.2.581-585.2001 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Journal of Clinical Microbiology volume 39, issue 2, page 581-585 ISSN 0095-1137 1098-660X Microbiology (medical) journal-article 2001 crasmicro https://doi.org/10.1128/jcm.39.2.581-585.2001 2023-10-09T16:09:18Z ABSTRACT Since January 1996, and over a 3-year time span, a significant spread of serotype 6B multidrug-resistant (MDR) pneumococci, susceptible to penicillin and resistant to erythromycin, clindamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole, was noted in young carriers living in central and southern Greece. Using restriction fragment end labeling and penicillin binding protein (PBP) genotyping, we studied 41 serotype 6B penicillin-susceptible MDR pneumococci isolated during two independent studies in Greece. Forty (98%) of these 41 isolates were strongly related, representing a single lineage (genetic relatedness, ≥91%). The Greek isolates were closely related (genetic relatedness, ∼91%) to the penicillin-resistant MDR clone of serotype 6B that spread from Spain to Iceland in the late 1980s. Moreover, the Greek group of isolates was genetically distinct (genetic relatedness, ≤83%) from other penicillin-susceptible or -resistant serotype 6B strains from various parts of the world. All serotype 6B penicillin-susceptible MDR isolates displayed a penicillin-susceptible PBP 1A-2B-2X genotype. Our findings suggest that the penicillin-susceptible MDR 6B clone that was found in Greece between the years 1996 and 1999 represents the ancestor of the pandemic penicillin-resistant MDR clone 6B. Article in Journal/Newspaper Iceland ASM Journals (American Society for Microbiology - via Crossref) Journal of Clinical Microbiology 39 2 581 585 |
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ASM Journals (American Society for Microbiology - via Crossref) |
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English |
topic |
Microbiology (medical) |
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Microbiology (medical) Syrogiannopoulos, G. A. Bogaert, D. Grivea, I. N. Beratis, N. G. De Groot, R. Hermans, P. W. M. Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
topic_facet |
Microbiology (medical) |
description |
ABSTRACT Since January 1996, and over a 3-year time span, a significant spread of serotype 6B multidrug-resistant (MDR) pneumococci, susceptible to penicillin and resistant to erythromycin, clindamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole, was noted in young carriers living in central and southern Greece. Using restriction fragment end labeling and penicillin binding protein (PBP) genotyping, we studied 41 serotype 6B penicillin-susceptible MDR pneumococci isolated during two independent studies in Greece. Forty (98%) of these 41 isolates were strongly related, representing a single lineage (genetic relatedness, ≥91%). The Greek isolates were closely related (genetic relatedness, ∼91%) to the penicillin-resistant MDR clone of serotype 6B that spread from Spain to Iceland in the late 1980s. Moreover, the Greek group of isolates was genetically distinct (genetic relatedness, ≤83%) from other penicillin-susceptible or -resistant serotype 6B strains from various parts of the world. All serotype 6B penicillin-susceptible MDR isolates displayed a penicillin-susceptible PBP 1A-2B-2X genotype. Our findings suggest that the penicillin-susceptible MDR 6B clone that was found in Greece between the years 1996 and 1999 represents the ancestor of the pandemic penicillin-resistant MDR clone 6B. |
format |
Article in Journal/Newspaper |
author |
Syrogiannopoulos, G. A. Bogaert, D. Grivea, I. N. Beratis, N. G. De Groot, R. Hermans, P. W. M. |
author_facet |
Syrogiannopoulos, G. A. Bogaert, D. Grivea, I. N. Beratis, N. G. De Groot, R. Hermans, P. W. M. |
author_sort |
Syrogiannopoulos, G. A. |
title |
Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
title_short |
Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
title_full |
Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
title_fullStr |
Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
title_full_unstemmed |
Molecular Epidemiology of Penicillin-Susceptible, Multidrug-Resistant Serotype 6B Pneumococci Isolated from Children in Greece |
title_sort |
molecular epidemiology of penicillin-susceptible, multidrug-resistant serotype 6b pneumococci isolated from children in greece |
publisher |
American Society for Microbiology |
publishDate |
2001 |
url |
http://dx.doi.org/10.1128/jcm.39.2.581-585.2001 https://journals.asm.org/doi/pdf/10.1128/JCM.39.2.581-585.2001 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Clinical Microbiology volume 39, issue 2, page 581-585 ISSN 0095-1137 1098-660X |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/jcm.39.2.581-585.2001 |
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Journal of Clinical Microbiology |
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39 |
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2 |
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581 |
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585 |
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1781700565343928320 |