Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus
The visna viruses are antigenically related nononcogenic retroviruses of sheep. The original strain was isolated from the brain of a paralyzed sheep in Iceland during the 1940s. The prototype strains has been passed serially in sheep and has undergone progressive antigenic change. Previous reports h...
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American Society for Microbiology
1981
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crasmicro:10.1128/iai.32.3.1045-1050.1981 2024-06-23T07:54:02+00:00 Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus Narayan, O Clements, J E Griffin, D E Wolinsky, J S 1981 http://dx.doi.org/10.1128/iai.32.3.1045-1050.1981 https://journals.asm.org/doi/pdf/10.1128/iai.32.3.1045-1050.1981 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Infection and Immunity volume 32, issue 3, page 1045-1050 ISSN 0019-9567 1098-5522 journal-article 1981 crasmicro https://doi.org/10.1128/iai.32.3.1045-1050.1981 2024-06-03T08:10:48Z The visna viruses are antigenically related nononcogenic retroviruses of sheep. The original strain was isolated from the brain of a paralyzed sheep in Iceland during the 1940s. The prototype strains has been passed serially in sheep and has undergone progressive antigenic change. Previous reports have shown that such antigenic changes in visna virus can be reproduced in infected cell cultures treated with neutralizing antibody. We now show that the antigenic profiles of the emerging mutants directly reflect the nature of the selecting antibody. Mutants with minor antigenic changes were selected by "early" sera which had a limited neutralization range. Mutants with greater antigenic changes were selected by "late" sera with a wide neutralization range. Mutants selected by early sera emerged rapidly and consistently in cultures, and these were antigenically very similar to one another. Mutants rarely emerged in cultures treated with late sera, but these viruses showed major antigenic changes. The data suggest that the evolution of antigenic mutants of visna virus progresses by a series of minor mutations which accumulate under the selective pressure of antibody. Article in Journal/Newspaper Iceland ASM Journals (American Society for Microbiology) Infection and Immunity 32 3 1045 1050 |
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Open Polar |
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ASM Journals (American Society for Microbiology) |
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crasmicro |
language |
English |
description |
The visna viruses are antigenically related nononcogenic retroviruses of sheep. The original strain was isolated from the brain of a paralyzed sheep in Iceland during the 1940s. The prototype strains has been passed serially in sheep and has undergone progressive antigenic change. Previous reports have shown that such antigenic changes in visna virus can be reproduced in infected cell cultures treated with neutralizing antibody. We now show that the antigenic profiles of the emerging mutants directly reflect the nature of the selecting antibody. Mutants with minor antigenic changes were selected by "early" sera which had a limited neutralization range. Mutants with greater antigenic changes were selected by "late" sera with a wide neutralization range. Mutants selected by early sera emerged rapidly and consistently in cultures, and these were antigenically very similar to one another. Mutants rarely emerged in cultures treated with late sera, but these viruses showed major antigenic changes. The data suggest that the evolution of antigenic mutants of visna virus progresses by a series of minor mutations which accumulate under the selective pressure of antibody. |
format |
Article in Journal/Newspaper |
author |
Narayan, O Clements, J E Griffin, D E Wolinsky, J S |
spellingShingle |
Narayan, O Clements, J E Griffin, D E Wolinsky, J S Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
author_facet |
Narayan, O Clements, J E Griffin, D E Wolinsky, J S |
author_sort |
Narayan, O |
title |
Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
title_short |
Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
title_full |
Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
title_fullStr |
Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
title_full_unstemmed |
Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
title_sort |
neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus |
publisher |
American Society for Microbiology |
publishDate |
1981 |
url |
http://dx.doi.org/10.1128/iai.32.3.1045-1050.1981 https://journals.asm.org/doi/pdf/10.1128/iai.32.3.1045-1050.1981 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Infection and Immunity volume 32, issue 3, page 1045-1050 ISSN 0019-9567 1098-5522 |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/iai.32.3.1045-1050.1981 |
container_title |
Infection and Immunity |
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32 |
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3 |
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1045 |
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1050 |
_version_ |
1802645969525800960 |