Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia
ABSTRACT Diphtheria is under control in industrialized countries. However, single cases and outbreaks still occur and the disease is not completely understood. Forty-three individuals suspected of having diphtheria who were referred to the Infectious Disease Hospital of Arkhangelsk from December 199...
Published in: | Clinical and Vaccine Immunology |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Society for Microbiology
2006
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1128/cvi.00026-06 https://journals.asm.org/doi/pdf/10.1128/CVI.00026-06 |
id |
crasmicro:10.1128/cvi.00026-06 |
---|---|
record_format |
openpolar |
spelling |
crasmicro:10.1128/cvi.00026-06 2024-06-23T07:50:58+00:00 Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia Danilova, Elena Jenum, Pål A. Skogen, Vegard Pilnikov, Valentin F. Sjursen, Haakon 2006 http://dx.doi.org/10.1128/cvi.00026-06 https://journals.asm.org/doi/pdf/10.1128/CVI.00026-06 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Clinical and Vaccine Immunology volume 13, issue 6, page 627-632 ISSN 1556-6811 1556-679X journal-article 2006 crasmicro https://doi.org/10.1128/cvi.00026-06 2024-05-27T12:59:59Z ABSTRACT Diphtheria is under control in industrialized countries. However, single cases and outbreaks still occur and the disease is not completely understood. Forty-three individuals suspected of having diphtheria who were referred to the Infectious Disease Hospital of Arkhangelsk from December 1994 to March 1995 were included in this study. Fifteen patients were diagnosed as having diphtheria and received equine hyperimmune antidiphtheria toxin antiserum, and 28 were diagnosed as carriers, 12 with nondiphtherial tonsillitis or pharyngitis and 16 without symptoms. Serum samples were obtained on admission and during the course of the disease or during follow-up of carrier status. Samples were analyzed for antibodies against diphtheria toxin with both an in vitro neutralization test (NT) and a human-specific enzyme immunoassay. All of the cases but one were confirmed by a positive culture. Twelve patients had pharyngeal diphtheria, and three had combined laryngeal and pharyngeal disease. Half of the patients had life-threatening disease, and one died. On admission, the median antibody titers measured with the NT were 0.085 IU/ml for the patients, 5.12 IU/ml for the symptomatic carriers, and 10.24 IU/ml for the healthy carriers. All of the diphtheria patients but one and nine of the carriers (six symptomatic and three healthy) had increased antibody levels during the first 7 to 10 days after admission. No obvious correlation was revealed between the antibody level or its kinetics and the course of the disease. Antibody levels on admission of >1 IU/ml were associated with a low risk of diphtheria. Article in Journal/Newspaper Arkhangelsk ASM Journals (American Society for Microbiology) Clinical and Vaccine Immunology 13 6 627 632 |
institution |
Open Polar |
collection |
ASM Journals (American Society for Microbiology) |
op_collection_id |
crasmicro |
language |
English |
description |
ABSTRACT Diphtheria is under control in industrialized countries. However, single cases and outbreaks still occur and the disease is not completely understood. Forty-three individuals suspected of having diphtheria who were referred to the Infectious Disease Hospital of Arkhangelsk from December 1994 to March 1995 were included in this study. Fifteen patients were diagnosed as having diphtheria and received equine hyperimmune antidiphtheria toxin antiserum, and 28 were diagnosed as carriers, 12 with nondiphtherial tonsillitis or pharyngitis and 16 without symptoms. Serum samples were obtained on admission and during the course of the disease or during follow-up of carrier status. Samples were analyzed for antibodies against diphtheria toxin with both an in vitro neutralization test (NT) and a human-specific enzyme immunoassay. All of the cases but one were confirmed by a positive culture. Twelve patients had pharyngeal diphtheria, and three had combined laryngeal and pharyngeal disease. Half of the patients had life-threatening disease, and one died. On admission, the median antibody titers measured with the NT were 0.085 IU/ml for the patients, 5.12 IU/ml for the symptomatic carriers, and 10.24 IU/ml for the healthy carriers. All of the diphtheria patients but one and nine of the carriers (six symptomatic and three healthy) had increased antibody levels during the first 7 to 10 days after admission. No obvious correlation was revealed between the antibody level or its kinetics and the course of the disease. Antibody levels on admission of >1 IU/ml were associated with a low risk of diphtheria. |
format |
Article in Journal/Newspaper |
author |
Danilova, Elena Jenum, Pål A. Skogen, Vegard Pilnikov, Valentin F. Sjursen, Haakon |
spellingShingle |
Danilova, Elena Jenum, Pål A. Skogen, Vegard Pilnikov, Valentin F. Sjursen, Haakon Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
author_facet |
Danilova, Elena Jenum, Pål A. Skogen, Vegard Pilnikov, Valentin F. Sjursen, Haakon |
author_sort |
Danilova, Elena |
title |
Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
title_short |
Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
title_full |
Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
title_fullStr |
Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
title_full_unstemmed |
Antidiphtheria Antibody Responses in Patients and Carriers of Corynebacterium diphtheriaein the Arkhangelsk Region of Russia |
title_sort |
antidiphtheria antibody responses in patients and carriers of corynebacterium diphtheriaein the arkhangelsk region of russia |
publisher |
American Society for Microbiology |
publishDate |
2006 |
url |
http://dx.doi.org/10.1128/cvi.00026-06 https://journals.asm.org/doi/pdf/10.1128/CVI.00026-06 |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_source |
Clinical and Vaccine Immunology volume 13, issue 6, page 627-632 ISSN 1556-6811 1556-679X |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/cvi.00026-06 |
container_title |
Clinical and Vaccine Immunology |
container_volume |
13 |
container_issue |
6 |
container_start_page |
627 |
op_container_end_page |
632 |
_version_ |
1802641958245498880 |