In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica

With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active co...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Ingolfsdottir, K, Hjalmarsdottir, M A, Sigurdsson, A, Gudjonsdottir, G A, Brynjolfsdottir, A, Steingrimsson, O
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 1997
Subjects:
Iceland
Online Access:http://dx.doi.org/10.1128/aac.41.1.215
https://journals.asm.org/doi/pdf/10.1128/AAC.41.1.215
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Summary:With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.

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