Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan

Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Icelan...

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Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Ikeda, Tsubasa, Suzuki, Rihito, Jin, Wanchun, Wachino, Jun-ichi, Arakawa, Yoshichika, Kimura, Kouji
Other Authors: Japan Agency for Medical Research and Development
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 2021
Subjects:
Infectious Diseases
Pharmacology (medical)
Pharmacology
Iceland
Online Access:http://dx.doi.org/10.1128/aac.01482-21
https://journals.asm.org/doi/pdf/10.1128/AAC.01482-21
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spelling crasmicro:10.1128/aac.01482-21 2023-11-05T03:42:51+01:00 Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji Japan Agency for Medical Research and Development Japan Agency for Medical Research and Development 2021 http://dx.doi.org/10.1128/aac.01482-21 https://journals.asm.org/doi/pdf/10.1128/AAC.01482-21 en eng American Society for Microbiology https://doi.org/10.1128/ASMCopyrightv2 https://journals.asm.org/non-commercial-tdm-license Antimicrobial Agents and Chemotherapy volume 65, issue 12 ISSN 0066-4804 1098-6596 Infectious Diseases Pharmacology (medical) Pharmacology journal-article 2021 crasmicro https://doi.org/10.1128/aac.01482-21 2023-10-09T16:11:47Z Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Article in Journal/Newspaper Iceland ASM Journals (American Society for Microbiology - via Crossref) Antimicrobial Agents and Chemotherapy 65 12
institution Open Polar
collection ASM Journals (American Society for Microbiology - via Crossref)
op_collection_id crasmicro
language English
topic Infectious Diseases
Pharmacology (medical)
Pharmacology
spellingShingle Infectious Diseases
Pharmacology (medical)
Pharmacology
Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
topic_facet Infectious Diseases
Pharmacology (medical)
Pharmacology
description Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland.
author2 Japan Agency for Medical Research and Development
Japan Agency for Medical Research and Development
format Article in Journal/Newspaper
author Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
author_facet Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
author_sort Ikeda, Tsubasa
title Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_short Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_full Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_fullStr Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_full_unstemmed Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_sort isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in japan
publisher American Society for Microbiology
publishDate 2021
url http://dx.doi.org/10.1128/aac.01482-21
https://journals.asm.org/doi/pdf/10.1128/AAC.01482-21
genre Iceland
genre_facet Iceland
op_source Antimicrobial Agents and Chemotherapy
volume 65, issue 12
ISSN 0066-4804 1098-6596
op_rights https://doi.org/10.1128/ASMCopyrightv2
https://journals.asm.org/non-commercial-tdm-license
op_doi https://doi.org/10.1128/aac.01482-21
container_title Antimicrobial Agents and Chemotherapy
container_volume 65
container_issue 12
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