Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells
Infectious salmon anemia virus (ISAV) is an orthomyxovirus causing fetal disease of farmed Atlantic salmon, leading to considerable financial losses farmers around the world. In the present study, we sequenced and identified microRNAs (miRNAs) from Atlantic salmon kidney (ASK) cells infected with IS...
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crascipubl:10.1166/jnn.2021.19159 2024-04-28T08:13:16+00:00 Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells Suh, Sung-Suk 2021 http://dx.doi.org/10.1166/jnn.2021.19159 https://www.ingentaconnect.com/content/asp/jnn/2021/00000021/00000007/art00005 en eng American Scientific Publishers Journal of Nanoscience and Nanotechnology volume 21, issue 7, page 3673-3678 ISSN 1533-4880 Condensed Matter Physics General Materials Science Biomedical Engineering General Chemistry Bioengineering journal-article 2021 crascipubl https://doi.org/10.1166/jnn.2021.19159 2024-04-02T06:50:26Z Infectious salmon anemia virus (ISAV) is an orthomyxovirus causing fetal disease of farmed Atlantic salmon, leading to considerable financial losses farmers around the world. In the present study, we sequenced and identified microRNAs (miRNAs) from Atlantic salmon kidney (ASK) cells infected with ISAV. Based on initial experimental data derived from RNA-Seq analysis, a group of differentially expressed (DE) miRNAs from the infected ASK cells were selected for expression analysis and to identify their mRNA targets. Among the DE miRNAs, highest-ranked 19 up-or down-regulated miRNAs stood out as attractive candidates for a role in ISAV-related function, which displayed a clear tendency to be continuously upregulated or downregulated during viral infection. Interestingly, these miRNAs displayed significant relationships with immune system processes based on their mRNA targets. Besides, miR-148a/b and miR-152 can be putative anti-viral miRNAs by directly targeting viral genes such as HA, P3, and NP genes which are required for viral infection. Taken together, these data may provide new clues to understanding the molecular framework of immune defense response during viral infection. Article in Journal/Newspaper Atlantic salmon American Scientific Publishers Journal of Nanoscience and Nanotechnology 21 7 3673 3678 |
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American Scientific Publishers |
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English |
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Condensed Matter Physics General Materials Science Biomedical Engineering General Chemistry Bioengineering |
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Condensed Matter Physics General Materials Science Biomedical Engineering General Chemistry Bioengineering Suh, Sung-Suk Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
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Condensed Matter Physics General Materials Science Biomedical Engineering General Chemistry Bioengineering |
description |
Infectious salmon anemia virus (ISAV) is an orthomyxovirus causing fetal disease of farmed Atlantic salmon, leading to considerable financial losses farmers around the world. In the present study, we sequenced and identified microRNAs (miRNAs) from Atlantic salmon kidney (ASK) cells infected with ISAV. Based on initial experimental data derived from RNA-Seq analysis, a group of differentially expressed (DE) miRNAs from the infected ASK cells were selected for expression analysis and to identify their mRNA targets. Among the DE miRNAs, highest-ranked 19 up-or down-regulated miRNAs stood out as attractive candidates for a role in ISAV-related function, which displayed a clear tendency to be continuously upregulated or downregulated during viral infection. Interestingly, these miRNAs displayed significant relationships with immune system processes based on their mRNA targets. Besides, miR-148a/b and miR-152 can be putative anti-viral miRNAs by directly targeting viral genes such as HA, P3, and NP genes which are required for viral infection. Taken together, these data may provide new clues to understanding the molecular framework of immune defense response during viral infection. |
format |
Article in Journal/Newspaper |
author |
Suh, Sung-Suk |
author_facet |
Suh, Sung-Suk |
author_sort |
Suh, Sung-Suk |
title |
Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
title_short |
Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
title_full |
Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
title_fullStr |
Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
title_full_unstemmed |
Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells |
title_sort |
anti-viral micrornas profiling in infectious salmon anemia virus (isav)-infected atlantic salmon kidney (ask) cells |
publisher |
American Scientific Publishers |
publishDate |
2021 |
url |
http://dx.doi.org/10.1166/jnn.2021.19159 https://www.ingentaconnect.com/content/asp/jnn/2021/00000021/00000007/art00005 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Journal of Nanoscience and Nanotechnology volume 21, issue 7, page 3673-3678 ISSN 1533-4880 |
op_doi |
https://doi.org/10.1166/jnn.2021.19159 |
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Journal of Nanoscience and Nanotechnology |
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21 |
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7 |
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3673 |
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3678 |
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