Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation
Inflammation mediated by the innate immune system is the organism’s protective mechanism against infectious environmental risk factors. Uncontrolled acute inflammation can become chronic, contributing to various chronic inflammatory diseases such as arthritis, asthma, autoimmune diseases, and athero...
Published in: | Journal of Nanoscience and Nanotechnology |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Scientific Publishers
2021
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1166/jnn.2021.19158 https://www.ingentaconnect.com/content/asp/jnn/2021/00000021/00000007/art00086 |
id |
crascipubl:10.1166/jnn.2021.19158 |
---|---|
record_format |
openpolar |
spelling |
crascipubl:10.1166/jnn.2021.19158 2024-06-23T07:45:57+00:00 Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation Chae, Hae-Jung Seo, Jong Bae Kim, Sung-Hak Youn, Ei Joung Kim, Sanghee Suh, Sung-Suk 2021 http://dx.doi.org/10.1166/jnn.2021.19158 https://www.ingentaconnect.com/content/asp/jnn/2021/00000021/00000007/art00086 en eng American Scientific Publishers Journal of Nanoscience and Nanotechnology volume 21, issue 7, page 4098-4103 ISSN 1533-4880 journal-article 2021 crascipubl https://doi.org/10.1166/jnn.2021.19158 2024-05-30T08:13:19Z Inflammation mediated by the innate immune system is the organism’s protective mechanism against infectious environmental risk factors. Uncontrolled acute inflammation can become chronic, contributing to various chronic inflammatory diseases such as arthritis, asthma, autoimmune diseases, and atherosclerosis. Although microalgae are increasingly receiving attention as a source of bioactive molecules with therapeutic potential for various human diseases, the underlying mechanisms are not yet well understood. In the present study, we investigated the molecular mechanisms underlying the anti-inflammatory and anti-aging activities of ethanol extracts of Antarctic freshwater microalga Micractinium simplicissimum. Using RAW 264.7 macrophages, microalgal extracts exerted anti-inflammatory activity by regulating the major inflammatory indicators including cyclooxy-genase (COX)-2, interleukin (IL)-6, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and nitric oxide (NO). Besides, we observed the anti-aging activity of the microalgal extract by suppressing MMP-1 production in human dermal fibroblast. Taken together, these data suggest that anti-inflammatory and anti-aging activities of Antarctic freshwater microalga, Micractinium simplicissimum, can provide new clues to understanding the molecular link between inflammation and diseases, and be a potential anti-inflammatory agent. Article in Journal/Newspaper Antarc* Antarctic American Scientific Publishers Antarctic Journal of Nanoscience and Nanotechnology 21 7 4098 4103 |
institution |
Open Polar |
collection |
American Scientific Publishers |
op_collection_id |
crascipubl |
language |
English |
description |
Inflammation mediated by the innate immune system is the organism’s protective mechanism against infectious environmental risk factors. Uncontrolled acute inflammation can become chronic, contributing to various chronic inflammatory diseases such as arthritis, asthma, autoimmune diseases, and atherosclerosis. Although microalgae are increasingly receiving attention as a source of bioactive molecules with therapeutic potential for various human diseases, the underlying mechanisms are not yet well understood. In the present study, we investigated the molecular mechanisms underlying the anti-inflammatory and anti-aging activities of ethanol extracts of Antarctic freshwater microalga Micractinium simplicissimum. Using RAW 264.7 macrophages, microalgal extracts exerted anti-inflammatory activity by regulating the major inflammatory indicators including cyclooxy-genase (COX)-2, interleukin (IL)-6, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and nitric oxide (NO). Besides, we observed the anti-aging activity of the microalgal extract by suppressing MMP-1 production in human dermal fibroblast. Taken together, these data suggest that anti-inflammatory and anti-aging activities of Antarctic freshwater microalga, Micractinium simplicissimum, can provide new clues to understanding the molecular link between inflammation and diseases, and be a potential anti-inflammatory agent. |
format |
Article in Journal/Newspaper |
author |
Chae, Hae-Jung Seo, Jong Bae Kim, Sung-Hak Youn, Ei Joung Kim, Sanghee Suh, Sung-Suk |
spellingShingle |
Chae, Hae-Jung Seo, Jong Bae Kim, Sung-Hak Youn, Ei Joung Kim, Sanghee Suh, Sung-Suk Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
author_facet |
Chae, Hae-Jung Seo, Jong Bae Kim, Sung-Hak Youn, Ei Joung Kim, Sanghee Suh, Sung-Suk |
author_sort |
Chae, Hae-Jung |
title |
Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
title_short |
Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
title_full |
Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
title_fullStr |
Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
title_full_unstemmed |
Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation |
title_sort |
antarctic freshwater microalga, micractinium simplicissimum, suppresses inflammation |
publisher |
American Scientific Publishers |
publishDate |
2021 |
url |
http://dx.doi.org/10.1166/jnn.2021.19158 https://www.ingentaconnect.com/content/asp/jnn/2021/00000021/00000007/art00086 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Journal of Nanoscience and Nanotechnology volume 21, issue 7, page 4098-4103 ISSN 1533-4880 |
op_doi |
https://doi.org/10.1166/jnn.2021.19158 |
container_title |
Journal of Nanoscience and Nanotechnology |
container_volume |
21 |
container_issue |
7 |
container_start_page |
4098 |
op_container_end_page |
4103 |
_version_ |
1802643153269817344 |