Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents
Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule con...
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American Chemical Society (ACS)
2019
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cracsoc:10.26434/chemrxiv.9640862.v1 2024-04-07T07:55:14+00:00 Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents Lee, Hamilton Lumata, Jenica Luzuriaga, Michael A. Benjamin, Candace Brohlin, Olivia Parish, Christopher R. Nielsen, Steven O. Lumata, Lloyd Gassensmith, Jeremiah J. 2019 http://dx.doi.org/10.26434/chemrxiv.9640862.v1 https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c743f3337d6c513ee26cc4/original/supramolecular-enhancement-of-aminoxyl-orca-contrast-agents.pdf unknown American Chemical Society (ACS) https://creativecommons.org/licenses/by-nc-nd/4.0/ posted-content 2019 cracsoc https://doi.org/10.26434/chemrxiv.9640862.v1 2024-03-08T00:17:37Z Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus. Other/Unknown Material Orca ACS Publications |
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ACS Publications |
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description |
Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus. |
format |
Other/Unknown Material |
author |
Lee, Hamilton Lumata, Jenica Luzuriaga, Michael A. Benjamin, Candace Brohlin, Olivia Parish, Christopher R. Nielsen, Steven O. Lumata, Lloyd Gassensmith, Jeremiah J. |
spellingShingle |
Lee, Hamilton Lumata, Jenica Luzuriaga, Michael A. Benjamin, Candace Brohlin, Olivia Parish, Christopher R. Nielsen, Steven O. Lumata, Lloyd Gassensmith, Jeremiah J. Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
author_facet |
Lee, Hamilton Lumata, Jenica Luzuriaga, Michael A. Benjamin, Candace Brohlin, Olivia Parish, Christopher R. Nielsen, Steven O. Lumata, Lloyd Gassensmith, Jeremiah J. |
author_sort |
Lee, Hamilton |
title |
Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
title_short |
Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
title_full |
Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
title_fullStr |
Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
title_full_unstemmed |
Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents |
title_sort |
supramolecular enhancement of aminoxyl orca contrast agents |
publisher |
American Chemical Society (ACS) |
publishDate |
2019 |
url |
http://dx.doi.org/10.26434/chemrxiv.9640862.v1 https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c743f3337d6c513ee26cc4/original/supramolecular-enhancement-of-aminoxyl-orca-contrast-agents.pdf |
genre |
Orca |
genre_facet |
Orca |
op_rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.26434/chemrxiv.9640862.v1 |
_version_ |
1795672268412551168 |