Genetical and Geographic Studies on Isoniazid Inactivation

Rapid and slow inactivators of isoniazid are homozygotes, and intermediate inactivators are heterozygotes. There is no dominance between the two alleles. The chasm between Eskimos and Caucasians in isoniazid metabolism is bridged by our investigation of the races in the Far East.

Bibliographic Details
Published in:Science
Main Authors: Sunahara, Shigeichi, Urano, Motoyuki, Ogawa, Masatoshi
Format: Article in Journal/Newspaper
Language:English
Published: American Association for the Advancement of Science (AAAS) 1961
Subjects:
Chasm
eskimo*
Online Access:http://dx.doi.org/10.1126/science.134.3489.1530
https://www.science.org/doi/pdf/10.1126/science.134.3489.1530
Description
Summary:Rapid and slow inactivators of isoniazid are homozygotes, and intermediate inactivators are heterozygotes. There is no dominance between the two alleles. The chasm between Eskimos and Caucasians in isoniazid metabolism is bridged by our investigation of the races in the Far East.

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