RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses
Adapting to the Cold The gating of potassium channels is temperature sensitive, suggesting that these channels must adapt to function efficiently in the extreme cold. Garrett and Rosenthal (p. 848 , published online 5 January; see the Perspective by Ö hman ) show that the coding sequences for delaye...
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American Association for the Advancement of Science (AAAS)
2012
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Online Access: | http://dx.doi.org/10.1126/science.1212795 https://www.science.org/doi/pdf/10.1126/science.1212795 |
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craaas:10.1126/science.1212795 2024-09-15T17:43:13+00:00 RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses Garrett, Sandra Rosenthal, Joshua J. C. 2012 http://dx.doi.org/10.1126/science.1212795 https://www.science.org/doi/pdf/10.1126/science.1212795 en eng American Association for the Advancement of Science (AAAS) Science volume 335, issue 6070, page 848-851 ISSN 0036-8075 1095-9203 journal-article 2012 craaas https://doi.org/10.1126/science.1212795 2024-09-05T04:01:19Z Adapting to the Cold The gating of potassium channels is temperature sensitive, suggesting that these channels must adapt to function efficiently in the extreme cold. Garrett and Rosenthal (p. 848 , published online 5 January; see the Perspective by Ö hman ) show that the coding sequences for delayed rectifier potassium channels from an Antarctic and a tropical octopus differed at only four positions and gave functionally identical channels when expressed in Xenopus oocytes. A variation in temperature responses instead came from extensive messenger RNA editing. In particular, an edit that recoded an isoleucine to a valine in the pore of the Antarctic octopus channel greatly accelerated gating kinetics. Article in Journal/Newspaper Antarc* Antarctic Antarctic Octopus AAAS Resource Center (American Association for the Advancement of Science) Science 335 6070 848 851 |
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Open Polar |
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AAAS Resource Center (American Association for the Advancement of Science) |
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language |
English |
description |
Adapting to the Cold The gating of potassium channels is temperature sensitive, suggesting that these channels must adapt to function efficiently in the extreme cold. Garrett and Rosenthal (p. 848 , published online 5 January; see the Perspective by Ö hman ) show that the coding sequences for delayed rectifier potassium channels from an Antarctic and a tropical octopus differed at only four positions and gave functionally identical channels when expressed in Xenopus oocytes. A variation in temperature responses instead came from extensive messenger RNA editing. In particular, an edit that recoded an isoleucine to a valine in the pore of the Antarctic octopus channel greatly accelerated gating kinetics. |
format |
Article in Journal/Newspaper |
author |
Garrett, Sandra Rosenthal, Joshua J. C. |
spellingShingle |
Garrett, Sandra Rosenthal, Joshua J. C. RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
author_facet |
Garrett, Sandra Rosenthal, Joshua J. C. |
author_sort |
Garrett, Sandra |
title |
RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
title_short |
RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
title_full |
RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
title_fullStr |
RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
title_full_unstemmed |
RNA Editing Underlies Temperature Adaptation in K + Channels from Polar Octopuses |
title_sort |
rna editing underlies temperature adaptation in k + channels from polar octopuses |
publisher |
American Association for the Advancement of Science (AAAS) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1126/science.1212795 https://www.science.org/doi/pdf/10.1126/science.1212795 |
genre |
Antarc* Antarctic Antarctic Octopus |
genre_facet |
Antarc* Antarctic Antarctic Octopus |
op_source |
Science volume 335, issue 6070, page 848-851 ISSN 0036-8075 1095-9203 |
op_doi |
https://doi.org/10.1126/science.1212795 |
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Science |
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335 |
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6070 |
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848 |
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851 |
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1810490075348205568 |