Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome
Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adapt...
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American Association for the Advancement of Science (AAAS)
2023
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Online Access: | http://dx.doi.org/10.1126/sciadv.adh8990 https://www.science.org/doi/pdf/10.1126/sciadv.adh8990 |
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craaas:10.1126/sciadv.adh8990 2024-10-13T14:10:07+00:00 Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin de Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-Michel Montagnani, Caroline Destoumieux-Garzόn, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-Dupiol, Jeremie 2023 http://dx.doi.org/10.1126/sciadv.adh8990 https://www.science.org/doi/pdf/10.1126/sciadv.adh8990 en eng American Association for the Advancement of Science (AAAS) Science Advances volume 9, issue 36 ISSN 2375-2548 journal-article 2023 craaas https://doi.org/10.1126/sciadv.adh8990 2024-09-27T04:01:02Z Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adaptation may arise through genetics and epigenetics. In this study, we used (epi)genome-wide association mapping to show that oysters differentially exposed to POMS displayed genetic and epigenetic signatures of selection. Consistent with higher resistance to POMS, the genes targeted included many genes in several pathways related to immunity. By combining correlation, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of phenotypic variation was explained by interactions between the genetic and epigenetic information, ~14% by the genome, and up to 25% by the epigenome alone. Similar to genetically based adaptation, epigenetic mechanisms notably governing immune responses can contribute substantially to the rapid adaptation of hosts to emerging infectious diseases. Article in Journal/Newspaper Pacific oyster AAAS Resource Center (American Association for the Advancement of Science) Pacific Science Advances 9 36 |
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AAAS Resource Center (American Association for the Advancement of Science) |
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English |
description |
Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adaptation may arise through genetics and epigenetics. In this study, we used (epi)genome-wide association mapping to show that oysters differentially exposed to POMS displayed genetic and epigenetic signatures of selection. Consistent with higher resistance to POMS, the genes targeted included many genes in several pathways related to immunity. By combining correlation, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of phenotypic variation was explained by interactions between the genetic and epigenetic information, ~14% by the genome, and up to 25% by the epigenome alone. Similar to genetically based adaptation, epigenetic mechanisms notably governing immune responses can contribute substantially to the rapid adaptation of hosts to emerging infectious diseases. |
format |
Article in Journal/Newspaper |
author |
Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin de Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-Michel Montagnani, Caroline Destoumieux-Garzόn, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-Dupiol, Jeremie |
spellingShingle |
Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin de Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-Michel Montagnani, Caroline Destoumieux-Garzόn, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-Dupiol, Jeremie Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
author_facet |
Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin de Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-Michel Montagnani, Caroline Destoumieux-Garzόn, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-Dupiol, Jeremie |
author_sort |
Gawra, Janan |
title |
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
title_short |
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
title_full |
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
title_fullStr |
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
title_full_unstemmed |
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome |
title_sort |
epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to pacific oyster mortality syndrome |
publisher |
American Association for the Advancement of Science (AAAS) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1126/sciadv.adh8990 https://www.science.org/doi/pdf/10.1126/sciadv.adh8990 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Pacific oyster |
genre_facet |
Pacific oyster |
op_source |
Science Advances volume 9, issue 36 ISSN 2375-2548 |
op_doi |
https://doi.org/10.1126/sciadv.adh8990 |
container_title |
Science Advances |
container_volume |
9 |
container_issue |
36 |
_version_ |
1812817281937309696 |