The Australian dingo is an early offshoot of modern breed dogs
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (Ca...
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American Association for the Advancement of Science (AAAS)
2022
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Online Access: | http://dx.doi.org/10.1126/sciadv.abm5944 https://www.science.org/doi/pdf/10.1126/sciadv.abm5944 |
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craaas:10.1126/sciadv.abm5944 2024-10-13T14:07:44+00:00 The Australian dingo is an early offshoot of modern breed dogs Field, Matt A. Yadav, Sonu Dudchenko, Olga Esvaran, Meera Rosen, Benjamin D. Skvortsova, Ksenia Edwards, Richard J. Keilwagen, Jens Cochran, Blake J. Manandhar, Bikash Bustamante, Sonia Rasmussen, Jacob Agerbo Melvin, Richard G. Chernoff, Barry Omer, Arina Colaric, Zane Chan, Eva K. F. Minoche, Andre E. Smith, Timothy P. L. Gilbert, M. Thomas P. Bogdanovic, Ozren Zammit, Robert A. Thomas, Torsten Aiden, Erez L. Ballard, J. William O. 2022 http://dx.doi.org/10.1126/sciadv.abm5944 https://www.science.org/doi/pdf/10.1126/sciadv.abm5944 en eng American Association for the Advancement of Science (AAAS) Science Advances volume 8, issue 16 ISSN 2375-2548 journal-article 2022 craaas https://doi.org/10.1126/sciadv.abm5944 2024-09-27T04:00:11Z Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo. Article in Journal/Newspaper Greenland AAAS Resource Center (American Association for the Advancement of Science) Greenland Science Advances 8 16 |
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Open Polar |
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AAAS Resource Center (American Association for the Advancement of Science) |
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craaas |
language |
English |
description |
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo. |
format |
Article in Journal/Newspaper |
author |
Field, Matt A. Yadav, Sonu Dudchenko, Olga Esvaran, Meera Rosen, Benjamin D. Skvortsova, Ksenia Edwards, Richard J. Keilwagen, Jens Cochran, Blake J. Manandhar, Bikash Bustamante, Sonia Rasmussen, Jacob Agerbo Melvin, Richard G. Chernoff, Barry Omer, Arina Colaric, Zane Chan, Eva K. F. Minoche, Andre E. Smith, Timothy P. L. Gilbert, M. Thomas P. Bogdanovic, Ozren Zammit, Robert A. Thomas, Torsten Aiden, Erez L. Ballard, J. William O. |
spellingShingle |
Field, Matt A. Yadav, Sonu Dudchenko, Olga Esvaran, Meera Rosen, Benjamin D. Skvortsova, Ksenia Edwards, Richard J. Keilwagen, Jens Cochran, Blake J. Manandhar, Bikash Bustamante, Sonia Rasmussen, Jacob Agerbo Melvin, Richard G. Chernoff, Barry Omer, Arina Colaric, Zane Chan, Eva K. F. Minoche, Andre E. Smith, Timothy P. L. Gilbert, M. Thomas P. Bogdanovic, Ozren Zammit, Robert A. Thomas, Torsten Aiden, Erez L. Ballard, J. William O. The Australian dingo is an early offshoot of modern breed dogs |
author_facet |
Field, Matt A. Yadav, Sonu Dudchenko, Olga Esvaran, Meera Rosen, Benjamin D. Skvortsova, Ksenia Edwards, Richard J. Keilwagen, Jens Cochran, Blake J. Manandhar, Bikash Bustamante, Sonia Rasmussen, Jacob Agerbo Melvin, Richard G. Chernoff, Barry Omer, Arina Colaric, Zane Chan, Eva K. F. Minoche, Andre E. Smith, Timothy P. L. Gilbert, M. Thomas P. Bogdanovic, Ozren Zammit, Robert A. Thomas, Torsten Aiden, Erez L. Ballard, J. William O. |
author_sort |
Field, Matt A. |
title |
The Australian dingo is an early offshoot of modern breed dogs |
title_short |
The Australian dingo is an early offshoot of modern breed dogs |
title_full |
The Australian dingo is an early offshoot of modern breed dogs |
title_fullStr |
The Australian dingo is an early offshoot of modern breed dogs |
title_full_unstemmed |
The Australian dingo is an early offshoot of modern breed dogs |
title_sort |
australian dingo is an early offshoot of modern breed dogs |
publisher |
American Association for the Advancement of Science (AAAS) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1126/sciadv.abm5944 https://www.science.org/doi/pdf/10.1126/sciadv.abm5944 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Science Advances volume 8, issue 16 ISSN 2375-2548 |
op_doi |
https://doi.org/10.1126/sciadv.abm5944 |
container_title |
Science Advances |
container_volume |
8 |
container_issue |
16 |
_version_ |
1812814260406845440 |