Centre for Protein Engineering
The MRC Centre for Protein Engineering (or CPE) was a pioneering research unit in Cambridge, England, with a main focus on the structure, stability and activity of proteins and engineering of antibodies.Centre for Protein Engineering was established in 1990 as one of the MRC's first interdisciplinary research centres and one of the first research laboratories to bring together molecular biology, molecular genetics, biophysics and structural biology into one cohesive unit. It was formed around the research of two prominent scientists who invented protein engineering, Sir Alan Fersht and Sir Greg Winter. Sir Alan Fersht was Director of the MRC CPE from 1990 to 2010, with Greg Winter as Deputy Director. Both, Sir Alan Fersht and Sir Greg Winter were knighted in recognition of their work and for their outstanding contributions to science.
From 1990 to 2010 the unit has been extremely successful, both academically and commercially. All of Sir Alan's work on protein folding and much of Sir Greg's pioneering work to humanise antibodies was carried out at CPE. For example, Cambridge Antibody Technology was a biotechnology company founded by Sir Greg Winter in 1989 that was bought for £702 million in 2006 by AstraZeneca.
Another successful project that was started at CPE and maintained there until 2010 was the Structural Classification of Proteins database (or SCOP). Over the years SCOP has supported the development of computational tools and contributed to the understanding of protein repertoire, of how proteins relate to each other and how their structures and functions evolved.
The MRC Centre for Protein Engineering closed its doors at the end of September 2010, following the retirement of its director, Sir Alan Fersht. Nearly all of the CPE staff, including those maintaining the Structural Classification of Proteins database, and its infrastructure were incorporated into the MRC Laboratory of Molecular Biology (LMB). Provided by Wikipedia
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1by Wilmotte, Annick, Renard, Marine, Lara, Yannick, Cornet, Luc, Baurain, Denis, Waleron, Malgorzata, Waleron, KzryzstofContributors: “...Centre for Protein Engineering...”
Published 2015
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2by Tytgat, Bjorn, Verleyen, Elie, Sweetlove, Maxime, D'hondt, Sofie, Clerck, Pia, Van Ranst, Eric, Peeters, Karolien, Roberts, Steven, Namsaraev, Zorigto, Wilmotte, Annick, Vyverman, Wim, Willems, AnneContributors: “...Centre for Protein Engineering...”
Published in FEMS Microbiology Ecology (2016)
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3by Taton, Arnaud, Wilmotte, Annick, Smarda, Jan, Elster, Josef, Komarek, JiriContributors: “...Centre for Protein Engineering...”
Published in Polar Biology (2011)
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4Comparison of Microphototrophic Communities Living in Different Soil Environments in the High Arcticby Pushkareva, Ekatarina, Wilmotte, Annick, Laska, Kamil, Elster, JosefContributors: “...Centre for Protein Engineering...”
Published in Frontiers in Ecology and Evolution (2019)
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5by Wilmotte, Annick, Pessi, Igor Stelmach, Velazquez, David, durieu, Benoit, Lara, Yannick, Laughinghouse, Haywood DailContributors: “...InBios-Centre for Protein Engineering...”
Published 2021
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6by Wilmotte, Annick, Pessi, Igor Stelmach, Velazquez, David, Durieu, Benoit, Laughinghouse IV, HaywoodContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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7by Wilmotte, Annick, Pessi, Igor Stelmach, Velazquez, David, Laughinghouse IV, HaywoodContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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8by Wada, Tomotake, Koyama, Hiroshi, Kudoh, Sakae, Imura, Satoshi, Kviderova, Jana, Simek, Miroslav, Verleyen, Elie, Wilmotte, Annick, Elster, JosefContributors: “...Biological Sciences from Molecules to Systems - inBioS-Centre for Protein Engineering...”
Published 2020
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9by Wilmotte, AnnickContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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10by Wilmotte, Annick, Savaglia, Valentina, Durieu, Benoit, Lambrechts, sam, Willems, Anne, Vanhellemont, Quinten, Van de putte, Anton, Van De Vijver, Bart, Tytgat, Bjorn, Verleyen, Elie, Vyverman, WimContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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11by Savaglia, Valentina, Lambrechts, Sam, Durieu, Benoit, Vanhellemont, Quinten, Tytgat, Bjorn, Verleyen, Elie, Willems, Anne, Vyverman, wim, Wilmotte, AnnickContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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12by Koyama, Hiroshi, Wada, Tomotake, Kudoh, Sakae, Imura, Satoshi, Kvíderová, Jana, Verleyen, Elie, Wilmotte, Annick, Elster, JosefContributors: “...Biological Sciences from Molecules to Systems - inBioS- Centre for Protein Engineering...”
Published 2020
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13by Pessi, Igor, Pushkareva, Ekaterina, Lara, Yannick, Borderie, Fabien, Wilmotte, Annick, Elster, JosefContributors: “...InBios-Centre for Protein Engineering...”
Published in Microbial Ecology (2019)
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14by Pessi, Igor, Pushkareva, Ekaterina, Lara, Yannick, Borderie, Fabien, Wilmotte, Annick, Elster, JosefContributors: “...InBios-Centre for Protein Engineering...”
Published in Microbial Ecology (2019)
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15by Pessi, Igor, Pushkareva, Ekaterina, Lara, Yannick, Borderie, Fabien, Wilmotte, Annick, Elster, JosefContributors: “...InBios-Centre for Protein Engineering...”
Published in Microbial Ecology (2019)
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16by Sonan, Guillaume K, Receveur-Brechot, Véronique, Duez, Colette, Aghajari, Nushin, Czjzek, Mirjam, Haser, Richard, Gerday, CharlesContributors: “...Centre d’Ingénierie des Protéines Université de Liège = Centre for Protein Engineering University...”
Published in Biochemical Journal (2007)
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17by Sonan, Guillaume K, Receveur-Brechot, Véronique, Duez, Colette, Aghajari, Nushin, Czjzek, Mirjam, Haser, Richard, Gerday, CharlesContributors: “...Centre d’Ingénierie des Protéines Université de Liège = Centre for Protein Engineering University...”
Published in Biochemical Journal (2007)
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18by Sonan, Guillaume K, Receveur-Brechot, Véronique, Duez, Colette, Aghajari, Nushin, Czjzek, Mirjam, Haser, Richard, Gerday, CharlesContributors: “...Centre d’Ingénierie des Protéines Université de Liège = Centre for Protein Engineering University...”
Published in Biochemical Journal (2007)
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19by Sonan, Guillaume K, Receveur-Brechot, Véronique, Duez, Colette, Aghajari, Nushin, Czjzek, Mirjam, Haser, Richard, Gerday, CharlesContributors: “...Centre d’Ingénierie des Protéines Université de Liège = Centre for Protein Engineering University...”
Published in Biochemical Journal (2007)
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20by Hughes, Kevin, Constable, Andrew, Frenot, Yves, López-Martínez, Jerónimo, McIvor, Ewan, Njåstad, Birgit, Terauds, Aleks, Liggett, Daniela, Roldan, Gabriela, Wilmotte, Annick, Xavier, JoséContributors: “...InBios-Centre for Protein Engineering...”
Published in Environmental Science & Policy (2018)
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