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Biochemistry Biological Sciences not elsewhere classified Biophysics Biotechnology Chemical Sciences not elsewhere classified Ecology Environmental Sciences not elsewhere classified Molecular Biology adapted organisms aliphatic cluster aromatic amino acids aromatic cluster aromatic residues buried f26 buried inside buried phenylalanine central β common structure consisting div >< p exhibits thermal stability f26 changed f26 mutants compared f26 showed f26a mutants resulted fully elucidated high temperatures regardless including psychrophiles induced unfolding pamc 26621 psychrophilic arctic bacterium